PMID: 9556816Apr 29, 1998Paper

The effect of recombinant basic fibroblast growth factor (bFGF) in fibrin adhesive vehicle on the healing of ischaemic and normal incisional skin wounds

Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery
A Quirinia, A Viidik

Abstract

Normal and ischaemic incisional wounds in rats were treated with recombinant human basic fibroblast growth factor (rbFGF) in fibrin adhesive vehicle. After 10 days of healing the maximum load*S and stress*S (S denotes correction for shrinkage) of ischaemic wounds were increased by 45% and 39%, respectively, after treatment with 20 micrograms rbFGF and by 67% and 56% after treatment with 60 micrograms rbFGF. After 20 days only 20 micrograms rbFGF had any effect and increased maximum load*S by 31% and energy at maximum (load*S, stress*S) by 40%-48%. In normal wounds 0.6-20 micrograms and 60 micrograms rbFGF decreased the strength parameters by 19%-34% and 49%-52%, respectively, after 10 days. After 20 days there was no negative influence but 60 micrograms rbFGF increased the biomechanical properties by 15%-24%. Treatment with the fibrin adhesive vehicle alone decreased the biomechanical properties of ischaemic wounds after 20 days, and of normal wounds after both 10 and 20 days. In conclusion, rbFGF can improve the healing of ischaemic wounds and may be used in the treatment of ischaemic wounds in patients, but it can have negative effects on normal wound healing.

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Citations

Jul 23, 2003·British Journal of Plastic Surgery·F ZhangW C Lineaweaver
May 29, 2004·Annals of Surgery·William C LineaweaverFeng Zhang
Nov 4, 2000·Expert Opinion on Investigational Drugs·R A Clark
May 1, 2013·Journal of Biomedical Materials Research. Part a·Emmanuel E SadavaYuri W Novitsky
Jan 24, 2008·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Yuko FujiharaTsuyoshi Takato
Mar 23, 2012·Journal of Cellular and Molecular Medicine·Raymund E HorchAndreas Arkudas
Jan 30, 2003·The British Journal of Surgery·S P BennettS L Schor
Aug 27, 2015·Journal of Diabetes Science and Technology·Ulrike KluehDonald L Kreutzer
Mar 9, 2007·The International Journal of Lower Extremity Wounds·N Papanas, E Maltezos
Sep 7, 2007·Birth Defects Research. Part A, Clinical and Molecular Teratology·Hideyuki IwayamaNorishi Ueda
Apr 17, 2010·Annals of Surgery·Patricia L DanielsenLars N Jorgensen

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