The effect of recombinant bone morphogenetic protein-2 in revision tibiotalocalcaneal arthrodesis: utilization of the Retrograde Arthrodesis Intramedullary Nail database

The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons
J George DeVriesChristopher F Hyer

Abstract

The use of bone morphogenetic protein-2 (BMP-2) has been recommended for high-risk fusions and nonunion. Patients undergoing revisional tibiotalocalcaneal (TTC) arthrodesis via a retrograde arthrodesis nail to evaluate the influence of BMP-2 on rate of fusion in this high-risk population are presented. A retrospective chart and radiographic review were performed on 23 patients with failed prior fusion attempts at the ankle treated with retrograde intramedullary nailing. Sixteen patients were treated without BMP-2 (None group) and 7 were treated with BMP-2 (BMP group). The primary and secondary end-points were successful fusion, and time to fusion, respectively, with a variety of variables evaluated for influence. Other than the use of BMP-2, there were no statistical differences in the patient population. Overall, 11 of 16 ankles (68.8%) in the None group and 5 of 7 ankles (71.4%) in the BMP group resulted in a stable, functional limb. Rate of complication was similar between the 2 groups (p > .05). Time to radiographic ankle union was 115.2 and 184.0 days in the None and BMP groups (p > .05). The effect of BMP-2 on revisional TTC fusions with retrograde nails is reported here. The overall result as a stable, functional limb wa...Continue Reading

References

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Citations

Aug 31, 2013·Clinical Orthopaedics and Related Research·Mitchell S FourmanAustin T Fragomen
May 6, 2014·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Jochen PaulVictor Valderrabano
Oct 1, 2014·International Orthopaedics·Aurélien CourvoisierUNKNOWN French Study Group of BMP in Orthopedic Surgery
Feb 2, 2016·The Journal of the American Academy of Orthopaedic Surgeons·Eva U AsomughaIan J Alexander
Jan 25, 2016·The Journal of the American Academy of Orthopaedic Surgeons·Sheldon S LinEthan S Krell
May 28, 2015·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Dane K WukichBedda L Rosario
May 24, 2015·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Jeffrey E McAlisterChristy L Collins
Feb 9, 2013·Foot & Ankle International·J George DeVriesChristopher F Hyer
Apr 11, 2014·Foot & Ankle International·Bradly BussewitzGregory C Berlet
Jan 7, 2015·Foot & Ankle International·Julien Lucas Y HernandezOlivier Laffenetre
Jan 1, 2021·Expert Opinion on Biological Therapy·MaCalus V HoganJames H-C Wang

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