The effect of recurrence of HCV infection of life after liver transplantation

Transplant International : Official Journal of the European Society for Organ Transplantation
M D BonaP Burra

Abstract

The present study evaluated the quality of life (QOL) of adult cirrhotic patients before orthotopic liver transplantation (OLT), the effect of OLT on QOL in the long-term and the effect of HCV recurrence within medical complications on QOL. Three groups of patients were studied: 19 pre-OLT, 33 during the first year post-OLT and 41 1 to 5 years post-OLT. The patients completed questionnaires on QOL and underwent liver function tests, immunosuppressive drug blood level determinations and medical complications evaluation. Somatization and depression and anxiety scores improved significantly during the first year post-OLT compared with pre-OLT, but they worsened again during the 1-5-year period post-OLT. Physical functioning and life satisfaction scores improved significantly during the first year post-OLT completed with pre-OLT and the improvement persisted 1-5-year during the period post-OLT. Patients with HCV recurrence compared with patients without HCV recurrence during the first year post-OLT showed a significant worsening of most of the domains of QOL. In conclusion, OLT improved most of the domains of QOL by the end of the first post-transplant year, though the improvements did not all persist in the long-term. Recurrence o...Continue Reading

Citations

Jan 7, 2011·Journal of Transplantation·Marco Carbone, James Neuberger
Jun 2, 2012·World Journal of Gastroenterology : WJG·Piero AmodioLina Minazzato
Nov 26, 2015·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu
Apr 4, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Patrizia Burra, Manuela De Bona
Aug 17, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Edna Strauss, Maria Cristina Dias Teixeira
Apr 21, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Sammy SaabRonald W Busuttil
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Mar 29, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kara M SullivanJohn R Lake
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Mar 6, 2010·Metabolic Brain Disease·Francesca CampagnaP Amodio
May 7, 2021·Langenbeck's Archives of Surgery·Christian FazekasPeter Schemmer

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