The effect of remifentanil on cerebral blood flow velocity in children anesthetized with propofol

Paediatric Anaesthesia
A LagacéB Bissonnette

Abstract

Cerebrovascular stability and rapid anesthetic emergence are desirable features of a neuroanesthetic regimen. In this randomized crossover study the effect of a low-dose remifentanil infusion on cerebral blood flow velocity (CBFV) in children anesthetized with propofol was evaluated. Twenty healthy children aged 1-6 years undergoing urological surgery were enrolled. Following face mask induction with sevoflurane, anesthesia was maintained with a standardized propofol infusion. Rocuronium was used to facilitate tracheal intubation and normothermia, and normocapnia were maintained. All children received a caudal epidural block, and a transcranial Doppler probe was placed to measure middle cerebral artery blood flow velocity (Vmca). Each patient received a remifentanil regimen of 0.5 microg x kg(-1) followed by 0.2 microg x kg(-1) x min(-1) in a predetermined order of remifentanil + propofol or propofol alone. Vmca, mean arterial pressure (MAP) and heart rate (HR) were recorded simultaneously at equilibrium with and without remifentanil. The combination of remifentanil and propofol caused an 8.1% decrease in MAP (P = 0.0005) and an 11.8% decrease in HR (P < 0.0001) compared with propofol alone. Vmca was not different between the t...Continue Reading

References

Sep 1, 1986·Stroke; a Journal of Cerebral Circulation·C C BishopN L Browse
May 14, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·B Bissonnette, L N Benson
Aug 26, 1998·Current Opinion in Pediatrics·S Sudikoff, K Banasiak
Sep 5, 1998·Anesthesia and Analgesia·A ParisJ Schulte am Esch
May 13, 1999·Paediatric Anaesthesia·C S McFarlanT G Short
Oct 8, 1999·Anesthesia and Analgesia·Peter S A GlassScott Howell
Oct 11, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Cengiz KarsliBruno Bissonnette
Dec 13, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Claude AbdallahBruno Bissonnette
Apr 17, 2003·British Journal of Anaesthesia·M S VavilalaA M Lam

❮ Previous
Next ❯

Citations

Oct 8, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Ross BarlowBruno Bissonnette
Feb 24, 2010·Expert Opinion on Drug Safety·Charalampos StroumposGregorios A Paspatis
Jul 20, 2007·Acta Anaesthesiologica Scandinavica·V FodaleL B Santamaria
Mar 24, 2009·Anaesthesia·D F Marsh, B Hodkinson
Jan 28, 2010·Paediatric Anaesthesia·Maria SammartinoNicola Continolo
Feb 14, 2008·Acta Anaesthesiologica Scandinavica·V FodaleL B Santamaria

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.