The effect of repeated administration of antidepressant drugs on the thyrotropin-releasing hormone (TRH) content of rat brain structures

Psychoneuroendocrinology
E Przegaliński, L Jaworska

Abstract

The present study investigated the effect of repeated treatment with the antidepressant drugs imipramine, amitryptyline, citalopram and mianserin (10 mg/kg PO, twice daily for 14 days) on levels of thyrotropin-releasing hormone (TRH) in several brain structures (cerebral cortex, amygdala + pyriform cortex, hippocampus, nucleus accumbens, striatum and hypothalamus) of the rat. Amitriptyline caused a marked increase in the TRH content in the striatum and nucleus accumbens. Citalopram and mianserin produced a smaller but significant increase in the TRH content in the striatum only, while imipramine did not significantly affect the TRH concentrations in any of the brain structures. None of the antidepressant drugs administered acutely significantly affected the TRH concentrations in the nucleus accumbens or the striatum. These results indicate that changes in brain TRH induced by antidepressant drugs are not related to their therapeutic activity.

References

Oct 1, 1979·Psychoneuroendocrinology·M BuckleyA Darragh
Jan 1, 1979·Progress in Neurobiology·G G Yarbrough
Feb 28, 1978·Biochemical and Biophysical Research Communications·P J Fraker, J C Speck
Jun 1, 1985·British Journal of Pharmacology·V Reny-Palasse, R Rips
Jul 27, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·P May, R K Donabedian
Oct 1, 1973·The Journal of Endocrinology·S L JeffcoateN White
Jan 1, 1982·Progress in Neuro-psychopharmacology & Biological Psychiatry·J Hyttel

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Citations

Jan 15, 1993·Biological Psychiatry·R C SheltonP T Loosen
Dec 1, 1994·Biological Psychiatry·K T BradyT E Steele
Jun 23, 2001·Pharmacology, Biochemistry, and Behavior·G Bissette

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