Abstract
The present study investigated the effect of repeated treatment with the antidepressant drugs imipramine, amitryptyline, citalopram and mianserin (10 mg/kg PO, twice daily for 14 days) on levels of thyrotropin-releasing hormone (TRH) in several brain structures (cerebral cortex, amygdala + pyriform cortex, hippocampus, nucleus accumbens, striatum and hypothalamus) of the rat. Amitriptyline caused a marked increase in the TRH content in the striatum and nucleus accumbens. Citalopram and mianserin produced a smaller but significant increase in the TRH content in the striatum only, while imipramine did not significantly affect the TRH concentrations in any of the brain structures. None of the antidepressant drugs administered acutely significantly affected the TRH concentrations in the nucleus accumbens or the striatum. These results indicate that changes in brain TRH induced by antidepressant drugs are not related to their therapeutic activity.
References
Oct 1, 1978·Psychoneuroendocrinology·C B NemeroffA J Prange
Oct 1, 1979·Psychoneuroendocrinology·M BuckleyA Darragh
Jan 1, 1979·Progress in Neurobiology·G G Yarbrough
Feb 28, 1978·Biochemical and Biophysical Research Communications·P J Fraker, J C Speck
May 1, 1985·Neuropharmacology·C LightonC A Marsden
Jan 1, 1988·Journal of Neural Transmission·G Nowak, E Przegaliński
May 5, 1986·Life Sciences·N Fukuma, N Nihei
Jan 15, 1985·European Journal of Pharmacology·G GarchaT B Weeramanthri
Jun 1, 1985·British Journal of Pharmacology·V Reny-Palasse, R Rips
May 1, 1986·British Journal of Pharmacology·G W BennettC A Marsden
Jan 28, 1985·Life Sciences·M J KubekA Sattin
Jul 27, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·P May, R K Donabedian
Oct 1, 1973·The Journal of Endocrinology·S L JeffcoateN White
Sep 1, 1981·British Journal of Pharmacology·M Desiles, R Rips
Jan 1, 1982·Progress in Neuro-psychopharmacology & Biological Psychiatry·J Hyttel
Oct 1, 1981·Brain Research Bulletin·R B RastogiY D Lapierre
Jan 1, 1981·Neuroscience·O JohanssonE Spindel
Dec 15, 1983·Experientia·H LahtiR Hissa
Mar 19, 1984·Life Sciences·M J Kubek, A Sattin
Jan 1, 1984·Psychopharmacology·J HyttelJ Arnt
Aug 1, 1984·Neuropharmacology·C LightonA R Green
Jan 1, 1981·Psychoneuroendocrinology·C Kirkegaard
Citations
Jan 15, 1993·Biological Psychiatry·R C SheltonP T Loosen
Dec 1, 1994·Biological Psychiatry·K T BradyT E Steele
Jul 17, 1990·Neuroscience Letters·E PrzegalinskiR Konarska
Apr 16, 1999·European Journal of Pharmacology·A C McCreary, S L Handley
Jun 23, 2001·Pharmacology, Biochemistry, and Behavior·G Bissette
Jun 1, 1997·Neuropeptides·L Jaworska-FeilW Lasoń
Apr 24, 1999·Neuroscience·L Jaworska-FeilW Lasoń
Dec 1, 1995·Neuropeptides·L Jaworska-FeilW Lasoń
Feb 26, 1993·Brain Research·M R Jain, N K Subhedar
Sep 1, 1995·Neuropeptides·L Jaworska-FeilW Lasón
Sep 1, 1992·Neuropeptides·E PrzegalińskiK Gołembiowska
Sep 30, 2003·Molecular Psychiatry·A AlkemadeE Fliers