PMID: 7865176Jan 1, 1994Paper

The effect of reserpine treatment in vivo upon L-dopa and amphetamine evoked dopamine and DOPAC efflux in vitro from the corpus striatum of male rats

Journal of Neural Transmission. General Section
D E Dluzen, B Liu


In the present experiment we tested the effects of L-DOPA and amphetamine upon dopamine and DOPAC efflux in vitro from superfused corpus striatal tissue fragments of male rats who had been pretreated with reserpine. Male rats were treated with reserpine (5 mg/kg) or its vehicle at 24 hours prior to sacrifice and superfusion of the corpus striatum. Two different modes of L-DOPA (5 microM) and amphetamine (10 microM) stimulation, a brief 10-minute and a continuous 60-minute infusion, were tested for their ability to evoke striatal dopamine and DOPAC efflux. Depletion of monoamine storage capacity as achieved with reserpine significantly reduced the amount of basal dopamine and DOPAC released from superfused striatal tissue fragments of male rats. Although basal release rates were significantly reduced, the amount of dopamine and DOPAC released in response to in vitro L-DOPA infusions (10 or 60 minute infusions) was equivalent between reserpine and vehicle treated animals. In contrast, amphetamine stimulated DA release was significantly reduced in male rats treated with reserpine. For both L-DOPA and amphetamine, significantly greater amounts of dopamine were obtained with the 60- versus 10-minute infusion modes. These results dem...Continue Reading


Jan 11, 1992·Journal of Neural Transmission. General Section·D E Dluzen, F T Kratko
Aug 23, 1991·Brain Research·A Elverfors, H Nissbrandt
Feb 5, 1990·Brain Research·G L Snyder, M J Zigmond
Jan 1, 1990·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·T BrannanM Yahr
Jan 1, 1989·Journal of Neural Transmission·B Fornstedt, A Carlsson
Jun 1, 1989·Biochemical Pharmacology·N T Buu
May 1, 1989·Annals of Neurology·M M MouradianT N Chase
Aug 1, 1987·The Journal of Pharmacy and Pharmacology·D R CooperC D Marsden
Oct 1, 1987·The Journal of Pharmacy and Pharmacology·D R CooperC D Marsden
Jul 1, 1987·Neuroscience·B S StarrI C Kilpatrick
Aug 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·K L LeendersC D Marsden
Jan 1, 1987·Pharmacology & Therapeutics·R Duvoisin
Apr 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·R NiddamS Z Langer
Oct 1, 1974·Life Sciences·O Hornykiewicz
Oct 2, 1970·Science·K Y NgI J Kopin

❮ Previous
Next ❯


Mar 21, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M Laruelle

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.