The effect of resistance training on markers of immune function and inflammation in previously sedentary women recovering from breast cancer: a randomized controlled trial

Breast Cancer Research and Treatment
A D HagstromSimon Green

Abstract

The purpose of this randomized controlled trial was to determine the effects of resistance training (RT) on markers of inflammation and immune function in breast cancer survivors. Thirty-nine breast cancer survivors were randomly assigned to a RT (n = 20) or control (n = 19) group. RT performed supervized exercise three times per week. Natural killer cell (NK) and natural killer T-cell (NKT) function, and markers of inflammation (serum TNF-α, IL-6, IL-10, and CRP) were measured before and after training. Changes in NK and NKT cell function were analyzed using ANCOVA, with the change score the dependent variable, and the baseline value of the same variable the covariate. Effect sizes (ES) were calculated via partial eta-squared. We found a significant reduction, and large associated ESs, in the RT group compared to the control group for change in NK cell expression of TNF-α (p = 0.005, ES = 0.21) and NKT cell expression of TNF-α (p = 0.04, ES = 0.12). No differences were observed in any serum marker. Significant improvements in all measurements of strength were found in RT compared to control (p < 0.001; large ESs ranging from 0.32 to 0.51). These data demonstrate that RT has a beneficial effect on the NK and NKT cell expression...Continue Reading

References

Jan 1, 1990·Annual Review of Biochemistry·K I AraiT Yokota
Feb 1, 1991·Current Opinion in Immunology·B Perussia
Dec 1, 1987·British Journal of Cancer·P SelbyJ Humphreys
Mar 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S LevyT d'Angelo
Jan 1, 1980·Acta Radiologica. Oncology·H BlomgrenJ Wasserman
Sep 1, 1983·Journal of Surgical Oncology·W L GarnerC C Hoffmann
Jul 15, 1982·International Journal of Cancer. Journal International Du Cancer·E GorelikR B Herberman
Mar 1, 1994·Clinical and Diagnostic Laboratory Immunology·T L Whiteside, R B Herberman
Jul 1, 1995·International Journal of Sports Medicine·D C NiemanS L Nehlsen-Cannarella
Nov 11, 1993·International Journal of Cancer. Journal International Du Cancer·H F SewellR W Blamey
Oct 1, 1995·Current Opinion in Immunology·T L Whiteside, R B Herberman
Jul 11, 1998·European Journal of Applied Physiology and Occupational Physiology·W J KraemerK Häkkinen
May 5, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·G WinklerK Cseh
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Jun 9, 2000·Clinical and Experimental Immunology·R StaatsJ C Virchow
Jun 17, 2000·Archives of Physical Medicine and Rehabilitation·Y M NaD S Yoon
Nov 30, 2000·Immunology Today·D I GodfreyA G Baxter
Mar 23, 2001·Nature Immunology·M J Smyth, D I Godfrey
Feb 7, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J S GreiweC F Semenkovich
May 2, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Marjolein VisserTamara B Harris
Jun 27, 2002·British Journal of Cancer·N TsavarisD Boulamatsis
Oct 3, 2002·Nature Reviews. Immunology·Joseph A Trapani, Mark J Smyth
Feb 21, 2003·European Journal of Immunology·Thomas BauernhoferTheresa L Whiteside
Aug 15, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A D MartinM J Marfell-Jones
Sep 11, 2003·The Lancet Oncology·Peter W Szlosarek, Frances R Balkwill
Nov 12, 2003·Journal of Muscle Research and Cell Motility·B K PedersenB Saltin
Dec 23, 2004·American Journal of Physiology. Endocrinology and Metabolism·Michael J TothMichael J Previs
Mar 18, 2005·Journal of Applied Physiology·Anne Marie W Petersen, Bente Klarlund Pedersen
Mar 18, 2005·Journal of Applied Physiology·Adrian S FaireyJohn R Mackey
Jul 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thorsten HagemannFrances R Balkwill
Jul 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kathryn H SchmitzDouglas Yee
Nov 12, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Brian K McFarlinKyle L Timmerman
Nov 16, 2005·Medicine and Science in Sports and Exercise·Natalie A HutnickAndrea M Mastro
Mar 2, 2006·Journal of Strength and Conditioning Research·Birinder Singh B Cheema, Catherine A Gaul
Mar 7, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Peter SzlosarekFrances R Balkwill

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Citations

Apr 15, 2018·Breast Cancer Research and Treatment·Frederico Soares FalcettaDaniela Dornelles Rosa
Apr 27, 2019·Journal of Physical Activity & Health·Rochelle Rocha CostaLuiz Fernando Martins Kruel
May 21, 2019·Clinical Orthopaedics and Related Research·Parvaneh Taghavi Azar SharabianiKinda Khalaf
Nov 29, 2017·Journal of Aging and Physical Activity·Alex S RibeiroEdilson S Cyrino
Aug 25, 2017·BioMed Research International·Wanderson Divino Nilo Dos SantosCarlos Alexandre Vieira
Aug 24, 2017·Menopause : the Journal of the North American Menopause Society·Monica C SerraAndrew P Goldberg
Jan 7, 2018·Journal of Cancer Research and Clinical Oncology·Thorsten SchmidtChristoph Mundhenke
Sep 11, 2020·International Journal of Environmental Research and Public Health·Leidy Sofía Montaño-RojasJosé Antonio de Paz
Nov 23, 2017·British Journal of Sports Medicine·Sarah E Neil-SztramkoKristin L Campbell
Nov 5, 2016·Nutrition and Metabolic Insights·Salma A AbdelmagidDavid W L Ma
Jun 28, 2019·Frontiers in Physiology·Jonathan C McleodStuart M Phillips
Nov 17, 2017·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kerri M Winters-StoneNathan F Dieckmann
Jan 22, 2021·Annals of the New York Academy of Sciences·Zahra NodehiGhorban Taghizadeh
Nov 22, 2020·Journal of Bodywork and Movement Therapies·Marco Aurélio de Jesus LeiteNilson Penha-Silva
Mar 11, 2021·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Linda F WangG J van Londen
Apr 27, 2021·Journal of Strength and Conditioning Research·Jared RosenbergColin E Champ
Mar 8, 2021·Journal of Strength and Conditioning Research·Rafael F MoraesCarlos A Vieira
Oct 21, 2020·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Miri CohenShimon Pollack
Mar 20, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Tyler J BruinsmaKathleen M Sturgeon

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