The effect of respiratory syncytial virus on subsequent recurrent wheezing in atopic and nonatopic children.

The Journal of Allergy and Clinical Immunology
E A SimoesPalivizumab Long-Term Respiratory Outcomes Study Group

Abstract

Although respiratory syncytial virus (RSV) lower respiratory tract infections (LRTIs) in early life are followed by later airway hyperreactivity, it is unclear whether there is a causal relationship between this and an atopic diathesis. To separate the effects of RSV LRTI and an atopic diathesis on subsequent recurrent wheezing, we examined the protective effect of previous palivizumab administration against subsequent recurrent wheeze in infants with and without a family history of atopy. A prospective multicenter, matched, double cohort study was conducted in 27 centers in Europe and Canada. The rates of physician-diagnosed recurrent wheezing in premature infants <36 weeks gestation who had received palivizumab in the first year of life were compared to those of gestational age-matched controls. The relative protective effect of palivizumab on physician-diagnosed recurrent wheezing through the ages of 2 to 5 years was 68% in those with no family history of asthma (odds ratio, 0.32; (95% CI, 0.14-0.75; N = 146 palivizumab-treated, 171 untreated) and 80% in those with no family history of atopy or food allergies (odds ratio, 0.20; 95% CI, 0.07-0.59; N = 101 palivizumab-treated, 100 untreated). In contrast, there was no effect o...Continue Reading

References

Jan 19, 1995·The New England Journal of Medicine·F D MartinezW J Morgan
Feb 19, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D R O'Donnell, P J Openshaw
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·N SigursB Kjellman
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·C H BoskenJ M Samet
Apr 15, 2004·Allergy·Matthew MasoliUNKNOWN Global Initiative for Asthma (GINA) Program
Aug 31, 2004·Pediatric Pulmonology·Tessa GoetghebuerJeremy Hull
Sep 15, 2005·The Journal of Allergy and Clinical Immunology·Robert F LemanskeJames E Gern
Mar 14, 2007·The Journal of Allergy and Clinical Immunology·Merci M H KuselPeter D Sly
Apr 13, 2007·Pediatric Pulmonology·M L García-GarcíaP Pérez-Breña
Jun 26, 2007·The Journal of Pediatrics·Eric A F SimoesUNKNOWN Palivizumab Long-Term Respiratory Outcomes Study Group
Jun 21, 2008·American Journal of Respiratory and Critical Care Medicine·Daniel J JacksonRobert F Lemanske
Apr 14, 2009·The Journal of Allergy and Clinical Immunology·Kecia N CarrollTina V Hartert

❮ Previous
Next ❯

Citations

Aug 23, 2012·Current Allergy and Asthma Reports·Dorothy S Cheung, Mitchell H Grayson
Mar 12, 2013·Current Allergy and Asthma Reports·Monica L GavalaJames E Gern
Oct 5, 2013·Current Allergy and Asthma Reports·T Prescott Atkinson
Apr 12, 2013·Clinical Reviews in Allergy & Immunology·Andrea T BorchersLaurel J Gershwin
Jan 17, 2014·The Lancet. Respiratory Medicine·Oliver Fuchs, Erika von Mutius
May 10, 2013·The New England Journal of Medicine·Robert F Lemanske
May 10, 2013·The New England Journal of Medicine·Maarten O BlankenUNKNOWN Dutch RSV Neonatal Network
Apr 14, 2011·The Pediatric Infectious Disease Journal·Gayle Fischer Langley, Larry J Anderson
May 10, 2013·Current Opinion in Pediatrics·Giovanni Piedimonte
Dec 4, 2012·Viruses·Rachel J Derscheid, Mark R Ackermann
Jul 11, 2013·Clinical & Developmental Immunology·Marcello LanariGiacomo Faldella
Apr 9, 2014·Proceedings of the National Academy of Sciences of the United States of America·Andrew HiattLarry Zeitlin
Jun 22, 2014·International Immunopharmacology·Jonathan M GaffinWanda Phipatanakul
Oct 14, 2014·International Immunopharmacology·Jonathan M GaffinWanda Phipatanakul
Dec 3, 2014·Immunology and Allergy Clinics of North America·Regina K Rowe, Michelle A Gill
Apr 21, 2012·International Journal of Pediatrics·Joseph M Geskey, Stephen E Cyran
Feb 7, 2013·Current Opinion in Allergy and Clinical Immunology·Avraham Beigelman, Leonard B Bacharier
Oct 13, 2015·Expert Review of Respiratory Medicine·Haben Y AbrahaBosco Paes
Apr 16, 2015·Expert Review of Clinical Immunology·George V GuibasNikolaos G Papadopoulos
Aug 13, 2011·Expert Opinion on Biological Therapy·Kristin A Shadman, Ellen R Wald
Nov 2, 2014·BMC Infectious Diseases·Javier Díez-DomingoPablo Lázaro
Oct 24, 2012·Critical Care Nursing Clinics of North America·Judy Trivits Verger, Emily Elizabeth Verger
Oct 17, 2012·Seminars in Cutaneous Medicine and Surgery·Eric L SimpsonAmy S Paller
Jun 21, 2012·The Journal of Allergy and Clinical Immunology·Bo L K ChawesHans Bisgaard
Jun 30, 2012·The Journal of Allergy and Clinical Immunology·Darryl J Adamko, Michael Friesen
Nov 1, 2011·The Journal of Allergy and Clinical Immunology·Fernando D Martinez
Apr 5, 2011·The Journal of Allergy and Clinical Immunology·Marie von JagwitzChristian Vogelberg
Feb 5, 2011·Biochimica Et Biophysica Acta·Daniel E Dulek, R Stokes Peebles
Oct 30, 2010·Immunology and Allergy Clinics of North America·Terianne WongShyam Mohapatra
Mar 8, 2016·The Journal of Allergy and Clinical Immunology·Daniel J JacksonRobert F Lemanske
Oct 24, 2015·The Journal of Allergy and Clinical Immunology·Kazuko SugaiYoshimichi Okayama
Aug 8, 2015·Vaccine·Fernando P Polack
Oct 30, 2015·The Lancet Infectious Diseases·Katherine L O'BrienUNKNOWN Respiratory Syncytial Virus (RSV) Prevention study group
Mar 26, 2011·Pediatric Pulmonology·Melvin Wright, Giovanni Piedimonte
Feb 1, 2014·Pediatric Blood & Cancer·Sara Christina SadreameliJohn J Strouse
Jun 19, 2013·Pediatric Pulmonology·Mirella GaboliManuel Sánchez-Solís de Querol
Aug 21, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·Dimos GidarisMichael B Anthracopoulos
Nov 26, 2015·Clinics in Perinatology·Gloria S Pryhuber
Jan 3, 2015·Paediatric Respiratory Reviews·Katharine C Pike, Jane S A Lucas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Acute viral rhinopharyngitis

Acute viral rhinopharyngitis, also known as "common cold", is an acute, self-limiting viral infection of the upper respiratory tract involving the nose, sinuses, pharynx and larynx. Discover the latest research on acute viral rhinopharyngitis here.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.