PMID: 6165399May 18, 1981Paper

The effect of reticuloendothelial blockade on the blood clearance and tissue distribution of liposomes

Biochimica Et Biophysica Acta
R L SouhamiB E Ryman

Abstract

The blood clearance and tissue distribution of liposomes have been studied in mice subjected to reticuloendothelial blockade with dextran sulphate or carbon. The liposomes have been labelled in the lipid membranes with [3H]-cholesterol, [14C]phosphatidylcholine and/or 99mTc and the content with [14C]inulin. Reticuloendothelial blockade has been shown to slow the rate of clearance of neutral, positively and negatively charged liposomes and of both small unilamellar vesicles and large multilamellar vesicles. In normal animals, the liver uptake accounted for only 20-55% of the total injected radioactivity, the amount varying with the charge and size of the liposomes. Following blockade, the liver uptake of charged and neutral multilamellar liposomes was depressed. This was also true for negatively charged small unilamellar vesicles. The degree of depression of hepatic uptake was between 25-50%, which contrasts with the 80-90% reduction in uptake of a wholly phagocytosed particle (sheep red cells). This difference suggests that mechanisms other than Kupffer cell phagocytosis are also responsible for the normal uptake of liposomes into the liver. In the case of neutral and positively charged small unilamellar vesicles, delayed clear...Continue Reading

References

Feb 1, 1976·FEBS Letters·H M Patel, B E Ryman
Jan 1, 1978·Annual Review of Biophysics and Bioengineering·R E Pagano, J N Weinstein
Apr 7, 1975·Biochemical and Biophysical Research Communications·R L Juliano, D Stamp
Oct 1, 1972·Journal of Neurology, Neurosurgery, and Psychiatry·P BuxtonE P Young
Jun 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·T M Saba, N R Di Luzio

❮ Previous
Next ❯

Citations

Jan 1, 1994·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·R Goto, Y Ibuki
Jul 1, 2010·ACS Nano·Parmeswaran DiagaradjaneSunil Krishnan
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·K R PatelJ D Baldeschwieler
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A S RudolphW T Phillips
Dec 20, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert D ArnoldRobert M Straubinger
Sep 15, 2010·Indian Journal of Pharmaceutical Sciences·S Rathod, S G Deshpande
Jul 10, 1987·Biochimica Et Biophysica Acta·K J HwangP L Beaumier
May 4, 2001·Biochimica Et Biophysica Acta·R B CampbellR M Straubinger
Nov 15, 1983·Biochemical Pharmacology·C F GotfredsenM C Debroux-Guisset
Nov 15, 1983·Biochemical Pharmacology·C F GotfredsenA Goethals
Jul 18, 1984·Biochemical and Biophysical Research Communications·E F SommermanP R Cullis
May 1, 1983·Bioscience Reports·T N Palmer, J P Warner
Jan 12, 2007·Proceedings of the National Academy of Sciences of the United States of America·Dmitri SimbergErkki Ruoslahti
Aug 1, 1985·Journal of Pharmaceutical Sciences·C A Hunt, R D MacGregor
Jun 1, 1989·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M FedericoR L Magin
Jul 10, 2010·Nature Reviews. Drug Discovery·Robby A Petros, Joseph M DeSimone
Mar 7, 2019·The Journal of Pharmacology and Experimental Therapeutics·Patrick M Glassman, Vladimir R Muzykantov
Aug 12, 2020·Nature Materials·Ben OuyangWarren C W Chan
Sep 9, 2020·Nature Nanotechnology·Wilson PoonWarren C W Chan
Jul 26, 1991·Biochimica Et Biophysica Acta·P Hug, R G Sleight

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.