The effect of retinoids and butyrate on the expression of CRX and IRBP in retinoblastoma cells

Vision Research
J H BoatrightJ M Nickerson

Abstract

We sought to determine whether differentiation agents such as retinoids and butyrate regulate transcript levels of interphotoreceptor retinoid binding protein (IRBP) and cone rod homeobox (CRX), a homeodomain transcription factor that regulates IRBP promoter activity. WERI-Rb1 retinoblastoma cells were treated with all-trans retinol, all-trans retinoic acid, or butyrate. IRBP and CRX mRNA levels were determined by quantitative RT-PCR. Butyrate at low concentrations increased both mRNA levels but suppressed them at higher concentrations. Retinoic acid had minimal effects. Retinol increased CRX mRNA over four fold. IRBP and CRX transcript levels are sensitive to butyrate and CRX expression is sensitive to retinol.

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Oct 13, 2001·Brain Research·J H BoatrightJ M Nickerson

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Citations

Aug 23, 2003·Biochimica Et Biophysica Acta·Mika ReinisaloPaavo Honkakoski
Jul 21, 2006·The Journal of Biological Chemistry·Hemant KhannaAnand Swaroop
Apr 15, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Sarah GolzJörg Mey
Oct 6, 2012·Nutrition·Mrudula TiruvalluruGeereddy Bhanuprakash Reddy
Oct 4, 2005·Developmental Biology·Shubhangi N PrabhudesaiDeborah L Stenkamp
Jul 26, 2008·Experimental Eye Research·Eric H SouiedDebora B Farber
Jan 5, 2010·International Journal of Pharmaceutics·Poonam ChopraS Kevin Li
Jan 22, 2004·International Journal of Cancer. Journal International Du Cancer·Hye-Sook HanSoo-Jong Um
Oct 11, 2007·The Journal of Biological Chemistry·Seung-Ah LeeNatalia Y Kedishvili

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