The effect of ribavirin to treat previously healthy infants admitted with acute bronchiolitis on acute and chronic respiratory morbidity

Respiratory Medicine
M L EverardA D Milner

Abstract

The role of ribavirin in the treatment of acute bronchiolitis is controversial. It has been suggested that the use of ribavirin may be of benefit during the acute illness and may reduce subsequent recurrent respiratory morbidity. This randomized, double-blind, placebo-controlled study was designed to determine whether ribavirin administered during the acute illness would have an influence on respiratory morbidity during both the acute illness and during the following year. Bronchial reactivity 6 months after the acute illness was also assessed. Forty previously well infants with moderately severe acute bronchiolitis were recruited during three winter epidemics. Subjects received study medication for 18 h a day. Management was otherwise unaltered. Subjects were evaluated daily by the investigator and subsequently assessed at 6 weeks, 6 months and 1 year following the acute illness. Assessment of bronchial hyper-responsiveness was assessed at 6 months of age using total body plethysmography and an established ultra-sonically nebulized distilled water challenge. A total of 40 patients (21 ribavirin, 19 placebo) were entered into the study. The two groups did not differ with respect to age, gender or clinical severity on entry to t...Continue Reading

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Citations

Aug 6, 2004·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Mark L Everard
Jan 5, 2011·Immunology Letters·Susan M BuenoAlexis M Kalergis
Mar 30, 2010·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·J González de DiosUNKNOWN Grupo de Revisión del Proyecto aBREVIADo (BRonquiolitis-Estudio de Variabilidad, Idoneidad y Adecuación)
Mar 26, 2011·Pediatric Pulmonology·Melvin Wright, Giovanni Piedimonte
Oct 3, 2003·Expert Opinion on Pharmacotherapy·Simon Broughton, Anne Greenough
Oct 5, 2001·Expert Opinion on Pharmacotherapy·N J Snell
Apr 6, 2011·Journal of Ethnopharmacology·Rong HanYong-Hong Liao
Oct 14, 2005·Pediatric Case Reviews·Howard B Panitch
Feb 23, 2018·Infectious Diseases and Therapy·Eric A F SimõesXavier Carbonell-Estrany
Feb 15, 2002·Current Opinion in Pulmonary Medicine·Cory Schlesinger, Michael N Koss
Feb 3, 2016·The Cochrane Database of Systematic Reviews·Marta Roqué i FigulsJordi Vilaró
May 14, 2010·The Cochrane Database of Systematic Reviews·Kathleen Ventre, Adrienne Randolph

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