The effect of risperidone on nursing burden associated with caring for patients with dementia

Journal of the American Geriatrics Society
Lori FrankHenry Brodaty

Abstract

To compare risperidone treatment with placebo for the burden to nursing staff of older nursing-home residents with dementia. Randomized, double-blind, placebo-controlled trial. Long-term care institutions in Australia and New Zealand. Two hundred seventy-nine residents had evaluable data for comparison of oral risperidone with placebo treatment at 4 weeks, 8 weeks, and endpoint across the 12-week trial. The Modified Nursing Care Assessment Scale (M-NCAS) is a 28-item instrument that measures behavior occurrence in patients (patient outcome) and difficulty of those behaviors for nursing staff as rated by nurse carers (nurse outcome). Treatment groups were compared via analysis of covariance (ANCOVA). To aid score interpretation, M-NCAS effect sizes were examined by response category, with response defined as subjects with mean Cohen-Mansfield Agitation Inventory total aggression subscale score change of 4 points or greater, a clinical outcome for patients. Between-group ANCOVAs showed statistically significant reductions in nurse-rated M-NCAS scores from baseline to endpoint for the patients randomized to risperidone relative to placebo (P<.05). Effects were evident at 4 weeks and maintained over time. Effect sizes were moderate...Continue Reading

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Citations

Sep 1, 2005·Current Neurology and Neuroscience Reports·Dag AarslandClive Ballard
Jun 5, 2010·International Psychogeriatrics·Dallas SeitzDavid Conn
Jun 27, 2012·BMC Geriatrics·Adam L GordonUNKNOWN Medical Crises in Older People Study Group
Feb 20, 2016·Journal of the American Geriatrics Society·Pia KontosGary Naglie
Jan 24, 2012·Journal of Gerontological Nursing·Debra BakerjianMary Ersek
Mar 14, 2007·Journal of the American Medical Directors Association·Gwendolen T Buhr, Heidi K White
Aug 20, 2005·Journal of the American Geriatrics Society·Ali A Asghar AliStephen Read
Mar 1, 2006·Journal of the American Medical Directors Association·Gwendolen T Buhr, Heidi K White
Jan 4, 2006·Human Psychopharmacology·Mervat N KozmanStephen Curran
May 3, 2019·British Journal of Clinical Pharmacology·Sujita W NarayanHelga Zoega
Oct 4, 2008·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Orestes Vicente ForlenzaBreno Satler de Oliveira Diniz
Nov 21, 2020·Journal of the American Geriatrics Society·Tony PhamJoseph E Ibrahim

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