The effect of rosemary on the mutagenic activity of heterocyclic amines extracted from common food consumed in Saudi Arabia

International Journal of Food Sciences and Nutrition
Hala A Awney, Heba Sindi

Abstract

Meat intake may increase cancer risk as heterocyclic amines (HCAs) are one of the food mutagens produced in meat cooked at high temperature. The consumption of meat in Saudi Arabia is high compared with other developing countries and the incidence of cancer has been increasing during the past 30 years. The present study aimed to quantitatively determine the effect of rosemary on the mutagenic activity and the amount of HCAs formed in beef Shawerma, grilled chicken and fried liver as an attempt to minimize the carcinogenic risk of HCAs formed in these commonly consumed meat dishes. Surprisingly, rosemary extracts (2%, 5%, 10% and 15%) apparently enhanced the total amount of HCAs measured in beef Shawerma, whereas 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) was the only mutagenic amine inhibited by 2% rosemary with a reduction up to 61.6% compared with control. In grilled chicken, the total amount of HCAs measured in 2% rosemary samples was reduced seven-fold lower than the control level, whereas PhIp and 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (TrpP1) were inhibited to non-detectable levels. These data demonstrate that 2% rosemary may play an important role in attenuating the production of PhIP in both Shawerma an...Continue Reading

References

Jul 1, 1976·Journal of Agricultural and Food Chemistry·M YanoM Namiki
Jan 1, 1992·Free Radical Biology & Medicine·A M PearsonS D Aust
Sep 1, 1988·Mutation Research·X M ZhangM Nagao
Dec 1, 1986·American Journal of Epidemiology·S E NorellK L Wiechel
Aug 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·B N AmesF D Lee
Dec 15, 1994·International Journal of Cancer. Journal International Du Cancer·P KnektA Aromaa
May 1, 1994·American Journal of Public Health·J E Muscat, E L Wynder
Dec 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M Johansson, M Jägerstad
Mar 28, 1997·International Journal of Cancer. Journal International Du Cancer·M H WardS H Zahm
Jun 1, 1997·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K SkogM Jägerstad
Sep 16, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K I SkogM I Jägerstad
Apr 14, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Z BaloghA M Booren
Apr 12, 2002·Mutation Research·John H WeisburgerYukihiko Hara
Jun 18, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C M Lan, B H Chen
Jun 18, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K Skog, A Solyakov
Sep 28, 2002·Mutation Research·Kristin E AndersonFred F Kadlubar
Oct 31, 2002·Journal of Biochemical and Biophysical Methods·Siegfried ZöchlingWerner Pfannhauser
Mar 24, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·C M LanB H Chen
Mar 24, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·L WarzechaC Dobosz
Mar 24, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·P Vitaglione, V Fogliano
Apr 10, 2004·Cancer Science·Takashi SugimuraMinako Nagao
Oct 19, 2004·Seminars in Cancer Biology·Gerald N WoganLawrence A Loeb
May 26, 2005·Mutation Research·Margaretha Jägerstad, Kerstin Skog
Oct 13, 2006·Journal of Agricultural and Food Chemistry·Rosa BusquetsKerstin Skog
Jun 16, 2007·Advances in Experimental Medicine and Biology·Venugopal P Menon, Adluri Ram Sudheer
Oct 28, 2008·Journal of Agricultural and Food Chemistry·Armindo MeloIsabel M P L V O Ferreira
Feb 26, 2009·Journal of Food Science·J S SmithP Gadgil

❮ Previous
Next ❯

Citations

Jan 4, 2012·International Journal of Cancer. Journal International Du Cancer·Harald zur Hausen
Nov 30, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·An-Chin ChengMin-Hsiung Pan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.