The effect of rosiglitazone on insulin sensitivity and mid-thigh low-density muscle in patients with Type 2 diabetes

Diabetic Medicine : a Journal of the British Diabetic Association
J S NamH C Lee

Abstract

We examined the effect of rosiglitazone on insulin sensitivity, abdominal fat and mid-thigh intramuscular fat distribution, and plasma concentrations of adipocytokines in patients with Type 2 diabetes. Rosiglitazone was administered at a daily dose of 4 mg to 42 Type 2 diabetes patients [age 32-70 years, body mass index (BMI) 17.5-32.6 kg/m(2), 15 women, 27 men] for 12 weeks. Various anthropometric and metabolic profiles, plasma adiponectin, leptin, and resistin levels were measured, and insulin resistance was calculated from the short insulin tolerance test. Body fat composition was assessed by computed tomography. Twelve weeks' rosiglitazone treatment resulted in improved insulin resistance despite increases in body weight and BMI. There was a significant decrease in abdominal visceral adipose tissue area (145 +/- 65.6 vs. 129 +/- 73.1 cm(2), P = 0.049). Mid-thigh low-density muscle area (TLDMA) increased from 23 +/- 9.6 to 26 +/- 8.2 cm(2) (P = 0.009). There were significant changes in plasma adipocytokines, but they were not significantly correlated with changes in insulin resistance. Rosiglitazone treatment resulted in an improvement of insulin responsiveness in Type 2 diabetic subjects, which was associated with the redis...Continue Reading

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Citations

Jun 12, 2012·Journal of Lipid Research·Janice V HuangGregory G Schwartz
Aug 21, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Si-Zeng Chen, Jian-Dong Xiao
May 25, 2013·Diabetes Care·UNKNOWN TODAY Study Group
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Mar 20, 2012·The Journal of the Acoustical Society of America·Vikramjit MitraLouis Goldstein
Jun 1, 2017·Journal of Obesity & Metabolic Syndrome·Ki Dong KoKyu Rae Lee
Apr 21, 2019·Journal of Diabetes and Its Complications·Mohammed E Al-SofianiRita R Kalyani

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