Abstract
Background. Immune activation has been implicated in the excess mortality in human immunodeficiency virus (HIV)-infected patients, due to cardiovascular diseases and malignancies. Statins may modulate this immune activation. We assessed the capacity of rosuvastatin to mitigate immune activation in treatment-naive HIV-infected patients. Methods. In a randomized double-blind placebo-controlled crossover study, we explored the effects of 8 weeks of rosuvastatin 20 mg in treatment-naive male HIV-infected patients (n = 28) on immune activation markers: neopterin, soluble Toll-like receptor (TLR)2, sTLR4, interleukin (IL)-6, IL-1Ra, IL-18, d-dimer, highly sensitive C-reactive protein, and CD38 and/or human leukocyte antigen-DR expression on T cells. Baseline data were compared with healthy male controls (n = 10). Furthermore, the effects of rosuvastatin on HIV-1 RNA, CD4/CD8 T-cell count, and low-density lipoprotein cholesterol were examined and side effects were registered. Results. T-cell activation levels were higher in patients than in controls. Patients had higher levels of circulating IL-18, sTLR2, and neopterin (all P < .01). Twenty patients completed the study. Rosuvastatin increased the CD4/CD8 T-cell ratio (P = .02). No ...Continue Reading
References
Nov 20, 2002·Journal of Virology·Rasheed AhmadAli Ahmad
Jun 10, 2004·Atherosclerosis·Thomas FehrPeter Ammann
Oct 8, 2004·European Journal of Epidemiology·Jos W R Twisk
Dec 22, 2005·American Heart Journal·Hannes Franz AlberFranz Weidinger
Jan 18, 2006·Heart·S BrugalettaF Crea
Mar 18, 2006·Clinical and Experimental Immunology·W SongJ Tang
Jul 10, 2007·Lancet·José Valdez MadrugaUNKNOWN TITAN study group
Sep 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Norbert BlankHanns-Martin Lorenz
Dec 29, 2007·The Journal of Pathology·V Appay, D Sauce
Jul 3, 2008·JAMA : the Journal of the American Medical Association·Krishnan BhaskaranUNKNOWN CASCADE Collaboration
Jul 23, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Charlotte LewdenUNKNOWN ANRS EN19 Mortalité Study Group and Mortavic1
Aug 14, 2008·Pharmacogenetics and Genomics·Conrad P Hodgkinson, Shu Ye
Oct 24, 2008·PLoS Medicine·Lewis H KullerUNKNOWN INSIGHT SMART Study Group
Oct 25, 2008·Annual Review of Medicine·Daniel C DouekRichard A Koup
Nov 11, 2008·Current HIV Research·Leonardo CalzaFrancesco Chiodo
Nov 14, 2008·AIDS·Andrew N PhillipsJens D Lundgren
Mar 31, 2009·Lancet·Paul M RidkerUNKNOWN JUPITER Trial Study Group
Feb 18, 2011·The Journal of Infectious Diseases·Anuradha GanesanFrank Maldarelli
Mar 23, 2011·AIDS·Elisabeth AslangulDominique Costagliola
Jun 21, 2011·HIV Clinical Trials·I Marion de BoerPythia T Nieuwkerk
Jul 19, 2011·PloS One·Richard D MooreJoel E Gallant
Oct 13, 2011·BMJ : British Medical Journal·Margaret MayCaroline Sabin
Feb 9, 2012·AIDS·Anna C HearpsSuzanne M Crowe
May 25, 2012·The American Journal of Cardiology·Pythia T NieuwkerkErik S G Stroes
Mar 8, 2013·PloS One·Line D RasmussenNiels Obel
Jun 19, 2013·Immunological Reviews·Mirko Paiardini, Michaela Müller-Trutwin
Nov 21, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nicholas T FunderburgGrace A McComsey
Jan 15, 2014·The Journal of Infectious Diseases·Allison Ross EckardGrace A McComsey
Jul 22, 2014·Lancet·Colette J SmithJens D Lundgren
Nov 20, 2014·BMC Immunology·Jaap Ten OeverMihai G Netea
Dec 17, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Nicholas T FunderburgGrace A McComsey
Citations
Jul 30, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Simon B AscherMichelle M Estrella
Aug 12, 2017·Current Opinion in HIV and AIDS·Virginia A Triant, Steven K Grinspoon
May 29, 2018·Current Infectious Disease Reports·Mosepele MosepeleVirginia A Triant
Sep 13, 2016·AIDS Research and Human Retroviruses·Leonardo CalzaPierluigi Viale
Apr 30, 2016·AIDS Research and Therapy·Gabriella d'EttorreVincenzo Vullo