The Effect of Roux-en-Y Gastric Bypass Surgery in Morbidly Obese Patients on Pharmacokinetics of (Acetyl)Salicylic Acid and Omeprazole: the ERY-PAO Study

Obesity Surgery
Lieke Mitrov-WinkelmolenDaan J Touw

Abstract

Data on the absorption of orally administered drugs following Roux-en-Y gastric bypass (RYGB) surgery in obese patients are limited and inconclusive. As it is difficult to predict changes in absorption, studies on frequently used drugs in this population are necessary. Acetylsalicylic acid (ASA) and omeprazole are two commonly prescribed drugs in obese patients. In this repeated measures study, omeprazole and salicylic acid (SA) serum concentrations were measured before and after RYGB in 34 morbidly obese subjects. Time to maximum concentration (Tmax), lag time (Tlag), maximum concentration (Cmax), and area under the serum concentration versus time curve (AUC) were calculated for both drugs to determine possible differences in drug absorption after the procedure. For SA, Tmax significantly decreased after RYGB, while both Cmax and AUC0-24 significantly increased. For omeprazole, both Tmax and Tlag significantly decreased after RYGB, while Cmax significantly increased. Mean AUC0-12 significantly decreased post-surgery. The difference in AUC0-12 before and after surgery varied between subjects. Our study shows a faster absorption of both ASA and omeprazole after RYGB. The exposure to ASA is higher post-surgery, but the standard d...Continue Reading

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Citations

Feb 6, 2017·Expert Opinion on Drug Metabolism & Toxicology·Célia Lloret-Linares
Nov 16, 2017·Clinical Pharmacokinetics·Nicholas B Norgard
Jun 25, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Philip Carlo AngelesJøran Hjelmesaeth
Apr 2, 2019·Journal of Thrombosis and Haemostasis : JTH·Giovanna PetrucciBianca Rocca
Feb 27, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Liam A McLachlanIrene S Um
Aug 24, 2018·European Journal of Clinical Pharmacology·Manuela Moreno SantamaríaPilar Utrilla Navarro
Jul 3, 2019·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Célia Lloret-LinaresXavier Declèves
May 16, 2021·British Journal of Clinical Pharmacology·Jurjen S KingmaCatherijne A J Knibbe
Oct 26, 2021·Expert Review of Clinical Pharmacology·Kaifeng ChenQi Pei

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