Abstract
1. The cardiovascular activity of S-(+)-boldine, an aporphine alkaloid structurally related to papaverine, was determined. The work includes functional studies on guinea-pig isolated aorta contracted with noradrenaline, caffeine, KCl or Ca2+, and on guinea-pig trachea contracted with acetylcholine or histamine. 2. S-(+)-boldine inhibited in a concentration-dependent manner the contractile response evoked by noradrenaline (10 microM) in guinea-pig aorta (IC50 = 1.4 +/- 0.2 microM) while the KCl depolarizing solution (60 mM)- or the Ca2+ (1 mM)-induced contractions were only partially affected by boldine up to 300 microM. In contrast, papaverine relaxed noradrenaline (NA), KCl or Ca2+ induced contractions showing similar IC50 values in all cases. S-(+)-boldine had a greater potency on the contraction elicited by NA whereas papaverine acted in a non-selective manner. 3. S-(+)-boldine was found to be an alpha 1-adrenoceptor blocking agent in guinea-pig aorta as revealed by its competitive antagonism of noradrenaline-induced vasoconstriction (pA2 = 5.64 +/- 0.08), and its potency was compared with that of prazosin (pA2 = 8.56 +/- 0.24), a known potent alpha 1-adrenoceptor antagonist. In contrast, papaverine caused rightward shifts o...Continue Reading
References
Jan 11, 1992·Journal of Vascular Research·M A Oriowo, R R Ruffolo
Jun 1, 1992·British Journal of Pharmacology·M D IvorraP D'Ocon
Apr 1, 1992·The Journal of Pharmacy and Pharmacology·E AnselmiP D'Ocon
Sep 1, 1992·British Journal of Pharmacology·D M VeenstraF P Nijkamp
Jul 9, 1991·European Journal of Pharmacology·M T PiascikE E Soltis
Nov 1, 1991·British Journal of Pharmacology·C M TengT F Huang
Oct 1, 1991·Journal of Cardiovascular Pharmacology·R A JenkinR F Moulds
Nov 6, 1990·European Journal of Pharmacology·C HanK P Minneman
Feb 1, 1990·The Journal of Pharmacy and Pharmacology·M L CandenasC Advenier
Jul 1, 1988·British Journal of Pharmacology·P DevillierD Regoli
Jan 1, 1986·Annual Review of Physiology·P M VanhoutteD S Houston
Jul 15, 1985·The Biochemical Journal·R F IrvineC P Downes
Oct 1, 1988·Naunyn-Schmiedeberg's Archives of Pharmacology·K SatoH Karaki
Jan 1, 1985·Annals of the New York Academy of Sciences·E A Jaffe
Jul 1, 1972·European Journal of Pharmacology·C LugnierJ C Stoclet
Nov 27, 1980·Nature·R F Furchgott, J V Zawadzki
Oct 27, 1980·Life Sciences·I Cavero, A G Roach
Jul 1, 1984·British Journal of Pharmacology·C AdvenierA Renier
Sep 15, 1982·The Biochemical Journal·M J BerridgeM R Hanley
Jun 1, 1995·Pharmacology·S ChuliáM P D'Ocón
Dec 1, 1994·British Journal of Pharmacology·S ChuliáP D'Ocon
Oct 1, 1993·British Journal of Pharmacology·F N KoC M Teng
Jan 1, 1994·Fundamental & Clinical Pharmacology·M A Oriowo
Aug 1, 1994·British Journal of Pharmacology·F N KoC M Teng
May 1, 1993·British Journal of Pharmacology·R AboudJ R Docherty
Jun 1, 1993·British Journal of Pharmacology·M D IvorraP D'Ocon
Feb 9, 1993·European Journal of Pharmacology·M D IvorraM P D'Ocon
Aug 1, 1995·The Journal of Pharmacy and Pharmacology·S ChuliáM P D'Ocón
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD
Citations
Sep 27, 2003·European Journal of Pharmacology·Hisatoshi Tsuchida, Yasushi Ohizumi
Aug 1, 1997·British Journal of Pharmacology·J CortijoR C Small
Mar 14, 2002·European Journal of Pharmacology·Bachtiar IndraYasushi Ohizumi
Oct 14, 2005·Chemico-biological Interactions·Peter O'BrienHernán Speisky
Apr 16, 1998·Japanese Journal of Pharmacology·J J KangW M Fu
Feb 26, 2015·Pharmacological Reports : PR·Anna RapaczHenryk Marona
Dec 14, 2011·Experimental Biology and Medicine·Yeh-Siang LauMohd Rais Mustafa
May 25, 2011·European Journal of Pharmacology·Jacek Sapa, Monika Kubacka