The effect of Saccharomyces boulardii on Candida albicans-infected human intestinal cell lines Caco-2 and Intestin 407

FEMS Microbiology Letters
Anna MurzynDorota Dziadkowiec

Abstract

Saccharomyces boulardii is a probiotic strain that confers many benefits to human enterocolopathies and is used against a number of enteric pathogens. Candida albicans is an opportunistic pathogen that causes intestinal infections in immunocompromised patients, and after translocation into the bloodstream, is responsible for serious systemic candidiasis. In this study, we investigated the influence of S. boulardii cells and its culture extract on C. albicans adhesion to Caco-2 and Intestin 407 cell lines. We also tested the proinflammatory IL-1beta, IL-6 and IL-8 cytokine expression by C. albicans-infected Caco-2 cells, using real-time RT-PCR. We found that both S. boulardii and its extract significantly inhibited C. albicans adhesion to epithelial cell lines. The IL-8 gene expression by C. albicans-infected Caco-2 cells was suppressed by the addition of S. boulardii extract. Our results indicate that S. boulardii affects C. albicans adhesion and reduces cytokine-mediated inflammatory host response.

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Citations

Feb 7, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Shiuh-Bin FangHsu-Wei Fang
Dec 7, 2013·Fungal Genetics and Biology : FG & B·Tiantian WangXiaomin Zhao
Sep 6, 2014·Frontiers in Cellular and Infection Microbiology·Anna Krasowska, Karel Sigler
Dec 30, 2014·Inflammatory Bowel Diseases·Mathias L RichardHarry Sokol
Dec 7, 2016·Future Microbiology·Fernanda Lourenção BrighentiCristiane Yumi Koga-Ito
May 31, 2019·World Journal of Gastroenterology : WJG·Dorota Czerucka, Patrick Rampal
Oct 1, 2020·Journal of Fungi·Lohith KunyeitReeta P Rao
May 1, 2021·International Journal of Molecular Sciences·Daria AugustyniakFionnuala T Lundy

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