The effect of salicylate on the biliary excretion of 14C-bishydroxycoumarin in rat

British Journal of Pharmacology
H S ButtarB H Thomas

Abstract

1. The effect of intravenous sodium salicylate on the biliary excretion of 14C-bishydroxycoumarin ((14)C-BHC) was studied in rats.2. Salicylate (88.9 mg/kg) increased the biliary excretion of (14)C-radioactivity from a control value of 12.3 +/- 2.7% to 29.3 +/- 2.5% of the administered dose in 6 h after injection.3. During the 6 h period, 11% of the dose of radioactivity underwent biliary recycling in the salicylate-treated rats compared to only 6% in the absence of salicylate.4. About 15.3% of the radioactivity excreted in the bile of rats given BHC alone was detected as unchanged BHC, 8.6% was present as BHC-conjugate, conjugates of BHC metabolites accounted for 30.9%, and the remainder consisted of unidentified metabolites.5. Salicylate treatment did not significantly alter the excretory pattern of unchanged BHC and its metabolites.

References

Jan 8, 1971·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·S HusainL L Eisenbrandt
Mar 1, 1973·Canadian Journal of Physiology and Pharmacology·B H ThomasW Zeitz
Jul 1, 1971·Biochemical Pharmacology·S Garten, W D Wosilait
Oct 1, 1971·Toxicology and Applied Pharmacology·T F Slater, V B Delaney
Sep 2, 1971·The New England Journal of Medicine·J K Weser, E Sellers
Jan 1, 1971·Acta Pharmacologica Et Toxicologica·F W KossZ Kopitar
Jan 1, 1965·Acta Pharmacologica Et Toxicologica·F CHRISTENSEN
Dec 24, 1915·The Journal of Physiology·S Okada

Citations

Jun 1, 1974·Toxicology and Applied Pharmacology·B B ColdwellB H Thomas
Jun 1, 1980·Digestive Diseases and Sciences·M J CooperA R Moossa
Aug 1, 1979·The Journal of Pharmacy and Pharmacology·H S ButtarJ H Moffatt

Related Concepts

Metazoa
Biliary Sludge
Dicoumarin
Carbon Radioisotopes
Paper Chromatography (Procedure)
Feces
Glucuronic Acids
Salicylic Acids
Rats, Laboratory

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