The effect of salt and pH on the phase-transition behaviors of temperature-sensitive copolymers based on N-isopropylacrylamide

Biomaterials
Xue-Ming LiuChaobin He

Abstract

The salt and pH effects on the phase transition behaviors of temperature-sensitive hydrophilic and amphiphilic polymers containing copolymers of N-isopropylacrylamide as hydrophilic segments were investigated by UV and dynamic light scattering studies. The polymers used for this study include two hydrophilic polymers of HO-terminated poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide) (1) and HO-functionalized poly(N-isopropylacrylamide-co-N-hydroxylmethylacrylamide) (3), and their amphiphilic derivatives of poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide)-b-poly(D,L-lactide) (2) and cholesteryl-grafted poly(N-isopropylacrylamide-co-N-hydroxylmethylacrylamide) (4). With the increase of NaCl concentration, significant salt effects on their phase transition behaviors were observed. (1) Significant decreases in the lower critical solution temperatures of all polymers were observed, the salt effects were also characterized by a newly defined 'phase transition salt concentration'; (2) time-course UV spectroscopic studies showed that the phase transitions became faster and more complete with the increase of NaCl concentration, which were demonstrated by a newly defined 'phase transition constant'; (3) the salt exerted stronger...Continue Reading

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Citations

Sep 5, 2013·International Journal of Biological Macromolecules·Guiying LiJunshen Liu
Aug 1, 2015·Journal of Biomaterials Science. Polymer Edition·Ye TianDaopeng Dong
Oct 2, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Jia-You FangJiuan-Wen Hu
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Jun 30, 2007·Journal of Biomedical Materials Research. Part a·Na WangYouqing Shen
Sep 25, 2019·Materials·Jae Gwang KimJeong Jae Wie
Oct 30, 2014·Advanced Healthcare Materials·Ji LiuChristine Jérôme
Feb 27, 2018·Physical Review Letters·Falko SchmidtGiovanni Volpe
Dec 28, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yu ChengJie Wei

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