The effect of seizure focus on regional language processing areas.

Epilepsia
Elizabeth S DukeWilliam D Gaillard

Abstract

To determine the effect of seizure focus location within the left hemisphere on the expression of regional language dominance. In this cross-sectional study we investigated 90 patients (mean age 23.3 ± 12.9 years) with left hemisphere focal epilepsy (mean age onset 11.7 ± 8.3 years). Eighteen patients had a frontal lobe focus and 72 had a temporal lobe focus (43 mesial; 29 neocortical). Subjects performed an auditory word definition language paradigm using 3 Tesla blood oxygen level dependent (BOLD) EPI functional magnetic resonance imaging (fMRI). Data were analyzed in SPM2. Regional laterality indices (LIs) for inferior frontal gyrus (IFG), and Wernicke's area (WA), were calculated using a bootstrap method. Categorical language dominance and mean LI were analyzed. Mean WA LI was lower for subjects with a mesial temporal focus compared with a frontal focus (p = 0.04). There was a greater proportion of atypical language in WA for subjects with a mesial temporal focus compared with a frontal focus (χ(2) = 4.37, p = 0.04). WA LI did not differ for subjects with a neocortical focus compared with a mesial focus or a frontal focus. Mean IFG LI and proportion of atypical language in IFG were similar across seizure focus groups. Age a...Continue Reading

References

Sep 30, 1977·Annals of the New York Academy of Sciences·T Rasmussen, B Milner
Oct 1, 1987·Annals of Neurology·H T ChuganiJ C Mazziotta
Nov 5, 1999·Brain : a Journal of Neurology·J A SpringerW M Mueller
Jul 24, 2002·Neurology·J P SzaflarskiT A Hammeke
Feb 25, 2003·Human Brain Mapping·William D GaillardCecile B Grandin
Apr 8, 2004·Brain : a Journal of Neurology·F LiégeoisT Baldeweg
May 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nitin GogtayPaul M Thompson
Aug 25, 2004·Neuroimaging Clinics of North America·William Davis Gaillard
Sep 24, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elizabeth R SowellArthur W Toga
Jan 18, 2005·NeuroImage·Lionel ThivardStéphane Lehéricy
Nov 23, 2005·Neurology·M M BerlW D Gaillard
Dec 7, 2005·Brain : a Journal of Neurology·Bernd WeberGuillén Fernández
Jul 11, 2006·Epilepsia·Dianne P AndersonGraeme D Jackson
Oct 31, 2007·Neurology·W D GaillardW H Theodore
Apr 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Philip ShawSteve P Wise
Dec 9, 2008·Brain : a Journal of Neurology·J MbwanaW D Gaillard
Jul 27, 2010·Brain and Language·Madison M BerlWilliam Davis Gaillard

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Citations

May 18, 2013·Journal of the History of the Neurosciences·Peter J Snyder, Harry A Whitaker
Sep 12, 2013·Brain : a Journal of Neurology·Gerald PahsTorsten Baldeweg
Dec 3, 2014·Neuroimaging Clinics of North America·Umair J Chaudhary, John S Duncan
Dec 24, 2015·Epilepsia·Leigh N SepetaWilliam D Gaillard
Sep 17, 2013·Annals of Neurology·Madison M BerlWilliam D Gaillard
Apr 12, 2016·Epilepsy & Behavior : E&B·Alice MaulisovaVilem Novak
Jan 8, 2015·Frontiers in Neuroscience·Lorenzo CaciagliNeda Bernasconi
Mar 2, 2016·Lancet Neurology·John S DuncanSebastien Ourselin
Jan 16, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Karl-Heinz NenningSilvia B Bonelli
Feb 25, 2019·Seizure : the Journal of the British Epilepsy Association·Linda M Gonzalez, Jacquie A Wrennall

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