The effect of selective destruction and regeneration of rat Leydig cells on the intratesticular distribution of testosterone and morphology of the seminiferous epithelium

Journal of Andrology
J M BartlettR M Sharpe

Abstract

This study was designed to explore the relationship between the intratesticular distribution of testosterone and spermatogenesis by completely destroying the Leydig cells of mature male rats with injection of a single i.p. dose of ethane dimethanesulphonate. After such treatment, testosterone levels in serum, testicular interstitial fluid, seminiferous tubules, and whole testis declined significantly 6 to 24 hours after injection and fell below assay detection limits between 3 and 7 days. At 3 and 7 days, serum LH and FSH levels rose significantly and remained elevated up to 4 and 6 weeks, respectively, in comparison with vehicle-treated controls. Leydig cells disappeared from the interstitium by day 3, but between 2 and 4 weeks postinjection a new generation of fetal-like Leydig cells repopulated the testicular interstitium and, during weeks 6 to 10, were transformed into, or replaced by, Leydig cells with an adult type of morphology. Histologic examination of the seminiferous tubules showed progressive disruption of spermatogenesis between 3 and 14 days post-ethane dimethanesulphonate. The first histologic sign of spermatogenic damage was noted at day 3, with the occurrence of stage-specific degenerating pachytene primary spe...Continue Reading

References

Jul 1, 1975·Journal of Steroid Biochemistry·D E Bu'Lock, C M Jackson
Feb 1, 1986·Clinics in Endocrinology and Metabolism·R M Sharpe
Oct 1, 1984·Molecular and Cellular Endocrinology·M ParvinenI Huhtaniemi
Jul 1, 1983·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·R M Sharpe
Dec 1, 1980·The American Journal of Anatomy·H Elias, D M Hyde
Nov 20, 1952·Annals of the New York Academy of Sciences·C P LEBLOND, Y CLERMONT
Nov 1, 1961·Journal of Reproduction and Fertility·H JACKSONA W CRAIG

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Citations

Jan 1, 1989·Archives of Andrology·K J TeerdsC J Wensing
Jan 1, 1996·Journal of Toxicology. Clinical Toxicology·A K Susheela, P Jethanandani
Jan 16, 1998·Andrologia·G B ChainyL Samanta
Nov 20, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Eun-Yeung GongKeesook Lee
Feb 3, 2009·Journal of Molecular Histology·Cevat Aktas, Mehmet Kanter
Mar 24, 2009·International Journal of Andrology·Eddy RijntjesKatja J Teerds
Apr 21, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Guido VerhoevenKarel De Gendt
Sep 14, 2012·Toxicologic Pathology·Dianne CreasyKatharine Whitney
May 1, 2014·Spermatogenesis·Justin D Vidal, Katharine M Whitney
Jan 9, 2019·Frontiers in Endocrinology·Olayiwola O OduwoleIlpo T Huhtaniemi
Aug 1, 1987·International Journal of Andrology·P C O'LearyD M de Kretser
Sep 8, 2007·International Journal of Andrology·Carla Dal Bianco FernandezWilma De Grava Kempinas
Apr 17, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Jingjing GuoRen-Shan Ge
Feb 24, 2001·Toxicologic Pathology·D M Creasy
Feb 1, 1989·International Journal of Andrology·W D Ratnasooriya, R M Sharpe
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M L Meistrich
Jun 30, 2016·American Journal of Physiology. Endocrinology and Metabolism·Rasmani HazraCharles M Allan
Jul 26, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Amanda V AlbuquerqueHélio Chiarini-Garcia

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