The effect of sensory uncertainty due to amblyopia (lazy eye) on the planning and execution of visually-guided 3D reaching movements.

PloS One
Ewa Niechwiej-SzwedoAgnes M F Wong

Abstract

Impairment of spatiotemporal visual processing in amblyopia has been studied extensively, but its effects on visuomotor tasks have rarely been examined. Here, we investigate how visual deficits in amblyopia affect motor planning and online control of visually-guided, unconstrained reaching movements. Thirteen patients with mild amblyopia, 13 with severe amblyopia and 13 visually-normal participants were recruited. Participants reached and touched a visual target during binocular and monocular viewing. Motor planning was assessed by examining spatial variability of the trajectory at 50-100 ms after movement onset. Online control was assessed by examining the endpoint variability and by calculating the coefficient of determination (R(2)) which correlates the spatial position of the limb during the movement to endpoint position. Patients with amblyopia had reduced precision of the motor plan in all viewing conditions as evidenced by increased variability of the reach early in the trajectory. Endpoint precision was comparable between patients with mild amblyopia and control participants. Patients with severe amblyopia had reduced endpoint precision along azimuth and elevation during amblyopic eye viewing only, and along the depth a...Continue Reading

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Citations

Oct 6, 2012·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Agnes M F Wong
Dec 17, 2014·Frontiers in Human Neuroscience·Roshani GnanaseelanEwa Niechwiej-Szwedo
Mar 9, 2019·Investigative Ophthalmology & Visual Science·Michael D RichardsAgnes M F Wong
Nov 6, 2018·Molecular Autism·Danielle SmithHarriet A Allen
Jul 10, 2019·Neural Plasticity·Ewa Niechwiej-SzwedoAgnes M F Wong

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