PMID: 9535513Apr 16, 1998Paper

The effect of sera from women with systemic lupus erythematosus and/or antiphospholipid syndrome on rat embryos in culture

Reproductive Toxicology
A OrnoyZ Blumenfeld

Abstract

Women with systemic lupus erythematosus (SLE) with or without antiphospholipid antibodies (APLA) suffer from a high rate of recurrent abortions perhaps as a result of specific antibodies that may damage the conceptus. We studied the effects of sera from women with SLE--with or without--APLA and recurrent abortions on 10.5-d-old rat embryos in culture. This was compared to the results of culture on sera from control women and on rat sera. In addition, we studied sera from women with SLE with or without APLA after treatment with low doses of aspirin and glucocorticosteroids. Seventy-three percent of embryos cultured in sera from women with SLE with or without APLA were malformed in comparison to only 10.2% in embryos cultured on control sera and 5.4% in embryos cultured on rat sera. The rate of anomalies was reduced to 37.5% in embryos cultured on sera from women with SLE with or without APLA after treatment, as in 6 of 13 sera, the treatment reduced or prevented the occurrence of embryonic anomalies. When sera were divided in to low- and high-risk sera, the effect of treatment was even more significant, as the average percentage of embryonic anomalies per serum was reduced from 81.7 to 44.7%. Specific ultrastructural changes wer...Continue Reading

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Citations

Mar 17, 2004·Current Opinion in Obstetrics & Gynecology·Howard J A Carp
Jan 9, 2003·American Journal of Reproductive Immunology : AJRI·Reuvit HalperinDavid Schneider
Jan 9, 2003·American Journal of Reproductive Immunology : AJRI·S T MatalonA Ornoy
Jan 30, 2004·American Journal of Reproductive Immunology : AJRI·Shelly Tartakover MatalonAsher Ornoy
Jan 31, 2012·Journal of Autoimmunity·Howard J A CarpYehuda Shoenfeld
Jun 24, 2004·Birth Defects Research. Part A, Clinical and Molecular Teratology·Asher OrnoyRichard K Miller
Aug 21, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sumita VermaPaul J Thuluvath
May 18, 2011·Arthritis Care & Research·Jinoos YazdanyPatricia P Katz
Nov 1, 1999·Alternatives to Laboratory Animals : ATLA·F Bulic-JakušD Šerman

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Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.