Aug 1, 1984

The effect of serum growth factors and xyloside on molecular aging of proteoglycan in embryonal chick cartilage

Mechanisms of Ageing and Development
Z NevoZ Zadik


The effects of normal human serum, insulin-like growth factor and beta-D-xyloside on the synthesis of proteoglycan, as well as their differential effect on the synthesis of chondroitin sulfate and keratan sulfate side-chains, were studied in chick embryonal cartilage. The glycosaminoglycans found in the incubation medium were mainly intact carbohydrate moieties of partially degraded proteoglycan molecules, whereas the tissue-bound glycosaminoglycans were of intact proteoglycan molecules. In incubations with normal human serum, the synthesis of the chondroitin sulfate side-chains of the tissue-bound glycosaminoglycans was preferentially stimulated, while the percentage of medium glycosaminoglycan (out of the total glycosaminoglycan in tissue and medium) was reduced, compared to control incubations. In incubations with insulin-like growth factor, the synthesis of the keratan sulfate side-chains of the tissue-bound glycosaminoglycan was preferentially stimulated, whereas the percentage of the medium glycosaminoglycan resembled that of control incubations. In incubations with xyloside, a marked reduction of tissue-bound glycosaminoglycan was noticed, mainly of chondroitin sulfate chains, and only a slight decrease in keratan sulfat...Continue Reading

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Mentioned in this Paper

Keratan Sulfate
Growth Hormone Activity
Growth Substances
Phosphoglycerate Dehydrogenase Activity
Insulin B Chain

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