PMID: 6403680Apr 1, 1983Paper

The effect of severe zinc deficiency on activity of intestinal disaccharidases and 3-hydroxy-3-methylglutaryl coenzyme A reductase in the rat

The Journal of Nutrition
R L GebhardC J McClain

Abstract

Specific activities of five enzymes were measured in intestinal mucosa of zinc-deficient rats and compared to activities in appropriate zinc-sufficient controls. Three disaccharidases were found to be significantly reduced in zinc deficiency. Alkaline phosphatase, a zinc metalloenzyme, also showed reduced activity. Activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol synthesis, was elevated. It is possible that impaired carbohydrate digestion (reflected in disaccharidase activity) and even defective lipid absorption (reflected in reductase activity) may contribute to the poor nutrition and diarrhea of zinc deficiency.

Citations

Jan 1, 1985·Journal of the American College of Nutrition·C J McClain
Jul 19, 2008·Journal of Nutritional Science and Vitaminology·Yoko HorikawaNanaya Tamaki
Jun 17, 2009·Current Opinion in Gastroenterology·Melanie J Tuerk, Nasim Fazel
Jun 24, 2014·Indian Journal of Pediatrics·Ting-Ting ZouXue Zhan
Apr 17, 2015·Neural Plasticity·Guillermo VelaAndreas M Grabrucker
Apr 29, 1998·Journal of Pediatric Gastroenterology and Nutrition·M K Bhan, N Bhandari
Jan 16, 2007·Journal of Animal Physiology and Animal Nutrition·D CarlsonH D Poulsen
Feb 13, 2002·Journal of the American College of Nutrition·Waseem AltafRaul A Wapnir
Dec 17, 2003·Journal of Pediatric Gastroenterology and Nutrition·Shinjini BhatnagarMaharaj K Bhan
Jun 3, 2010·The Journal of International Medical Research·S MagginiD Hornig
Feb 13, 2009·Current Medical Research and Opinion·Gregory M PastoresAtul Mehta
Sep 28, 1995·The New England Journal of Medicine·S SazawalS Jalla
Oct 4, 2005·Free Radical Biology & Medicine·Bodiga Sreedhar, Krishnapillai Madhavan Nair

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