The effect of sevoflurane on interventions for blood loss during dilation and evacuation procedures at 18-24 weeks of gestation: a randomized controlled trial

Contraception
Elizabeth MicksJeffrey T Jensen

Abstract

The objective was to evaluate whether the use of sevoflurane during general anesthesia for dilation and evacuation (D&E) procedures increases the frequency of interventions to treat excess bleeding. A randomized, double-blinded, placebo-controlled trial of a standardized general anesthesia protocol with or without inhaled sevoflurane for D&Es between 18 and 24 weeks' gestation was performed. The primary outcome was need for any intervention to treat blood loss. Secondary outcomes included measured blood loss, procedure time, complications, side effects, patient satisfaction and provider ease of procedure. One hundred sixty subjects were randomized. Those in the sevoflurane group were slightly more likely to have interventions for bleeding as compared to those subjects who did not receive sevoflurane (25% versus 16.3%, p=.17) or a measured blood loss above 300 mL (15% versus 7.5%, p=.13); however, these differences could have arisen by chance. Most cases of excess bleeding required only minor interventions, including uterine massage and/or uterotonic agents. Procedure time, complications, side effects, satisfaction and ease of procedure were similar between groups. Addition of sevoflurane to general anesthesia during a D&E betwe...Continue Reading

References

Oct 1, 1989·Acta Anaesthesiologica Scandinavica·T K AbboudA Afrasiabi
Dec 1, 1985·British Journal of Anaesthesia·K M CollinsJ P Doyle
Jul 1, 1985·Anaesthesia·S L WestP D Browne
Jul 1, 1970·Anesthesiology·W H Forrest
Sep 1, 1972·Anesthesia and Analgesia·M W Galbert, A E Gardner
Feb 1, 1997·Anaesthesia and Intensive Care·N KumarasingheA W Stewart
Mar 3, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·N NathanP Feiss
Jan 10, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Michiaki YamakageAkiyoshi Namiki
Aug 24, 2004·International Journal of Obstetric Anesthesia·A ToscanoV A Peduto
May 1, 2007·American Journal of Obstetrics and Gynecology·Julie T CrawfordJohn Buckmaster
Apr 4, 2009·Contraception·Katharine O'ConnellUNKNOWN National Abortion Federation Members
Apr 9, 2009·Expert Opinion on Pharmacotherapy·Fabrice Michel, Jean-Michel Constantin
Dec 12, 2012·Contraception·Jennifer Kerns, Jody Steinauer
Jul 3, 2013·Obstetrics and Gynecology

❮ Previous
Next ❯

Citations

Oct 26, 2016·Obstetrics and Gynecology·Lyndsey S BensonSarah W Prager
Nov 5, 2016·Journal de gynécologie, obstétrique et biologie de la reproduction·T Linet
Mar 13, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·E Jackson, N Kapp
Jan 12, 2019·Anesthesiology Research and Practice·Camille A ClareMario A Inchiosa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.