Abstract
Sevoflurane is commonly used in general anesthesia for premature neonates. The main mechanism of retinopathy of prematurity (ROP) is increased levels of vascular endothelial growth factor (VEGF). For the investigation of sevoflurane's effect on angiogenesis, the angiogenesis and VEGF expression in the retina were measured after administering sevoflurane in an oxygen-induced retinopathy mice model. The mice were divided into the normoxic group (Nc and Ns group; n = 6) and the ROP group (C, Rc, and Rs group; n = 6). Rc group were exposed to 75% oxygen for 5 days beginning on postnatal day (P) 7, and then returned to room air. Age-matched mice in the C group were exposed to room air. To observe angiogenesis of the retina, the mice were sacrificed on P16. The Rs group was exposed to 2 vol% sevoflurane for 2 h on P12, P13, and P14 with 40% oxygen. The angiogenic area and the spreading distance of vessels on P4 were statistically decreased in the Ns group, compared to the Nc group. The avascular area on P16 was significantly increased and the expression of VEGF was suppressed in the Rs group compared to the Rc group. Sevoflurane can inhibit retinal angiogenesis via suppressing VEGF expression in an OIR mice model with exposure to rel...Continue Reading
References
Mar 22, 2000·Circulation Research·S Dimmeler, A M Zeiher
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jun 21, 2005·Journal of Cellular and Molecular Medicine·Joyce E Rundhaug
Jan 26, 2007·Investigative Ophthalmology & Visual Science·Joshua M BarnettJohn S Penn
Mar 3, 2007·Angiogenesis·Jing Chen, Lois E H Smith
Mar 6, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·D AnandC W Yoxall
Aug 10, 2007·Eye·R Hartrey
Sep 28, 2007·Paediatric Anaesthesia·Sophie HassidClaude Martin
Mar 19, 2009·Anesthesiology·Robert T WilderDavid O Warner
Oct 14, 2009·Archives of Ophthalmology·Dordi AustengGerd E Holmström
Apr 30, 2010·Bulletin of the World Health Organization·Stacy BeckPaul F A Van Look
May 21, 2010·Investigative Ophthalmology & Visual Science·Andreas StahlLois E H Smith
Nov 26, 2010·Paediatric Anaesthesia·Ling YuBaxian Yang
Dec 15, 2010·Current Opinion in Pediatrics·Jing ChenLois E Smith
Feb 5, 2011·Anesthesiology·George K IstaphanousAndreas W Loepke
Feb 22, 2012·Journal of Anesthesia·Hua LiangQiaoling Zhou
Jun 21, 2013·Lancet·Ann HellströmOlaf Dammann
Mar 4, 2014·Medical Gas Research·Lei ZhangZhongcong Xie
Feb 11, 2015·Surgery·Chuiliang LiuYujuan Li
May 12, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yi LuHong Jiang
May 17, 2015·Gene·Yan ZhangHai-Gen Liu
Nov 7, 2015·Brain Research·Zhongmeng LaiQingxiu Xu
Citations
Jul 12, 2019·Anesthesia and Analgesia·Juan P CataPer-Arne Lonnqvist
Feb 27, 2020·Journal of Anesthesia·Hyun-Su RiSeung-Hoon Baek
Jun 2, 2020·Future Oncology·Xuesong WangJin Gao
Nov 20, 2019·Anesthesia and Analgesia·Juan P CataPer-Arne Lonnqvist