The effect of short chain fatty acid administration on hepatic glucose, phosphate, magnesium and calcium metabolism

Advances in Experimental Medicine and Biology
R VeechE D Eanes

Abstract

Intra peritoneal administration of the short chain fatty acids, acetate, propionate and butyrate, in amounts calculated to reach 20 mM in total body water were given to fed and 48 hour starved male Wistar rats. One half hour after administration, the livers were freeze-clamped and the hepatic contents of various intermediary metabolites were measured. The liver content of total glycolytic intermediates was elevated by short chain fatty acids. In fed animals, the portion of glycolysis from fructose 1,6-bisphosphate (FBP) to PEP was elevated 2 to 4 fold. In 48 hour starved animals, where gluconeogenesis is active, the portion of the gluconeogenetic pathway from FBP to glucose was elevated 1.5 to 3.5 fold with the exception of the butyrate treated animals where blood glucose was not elevated. The metabolites of the hexose-monophosphate pathway that were measured, namely 6-phosphogluconate, ribulose 5-phosphate and xylose 5-phosphate were increased in both fed and starved animals. The free cytoplasmic [NAD+]/[NADH], [NADP+]/[NADPH], and [epsilon ATP]/[epsilon ADP] X [epsilon Pi] ratios were all decreased in both fed and starved animals after short chain fatty acid administration. The liver content of calcium increased 1.2 to 2 fold...Continue Reading

Citations

Apr 14, 2011·FEBS Letters·Christos Chinopoulos
May 5, 2011·Journal of Neuroscience Research·Christos Chinopoulos
Jan 1, 1988·Advances in Enzyme Regulation·R L Veech, W L Gitomer
Apr 2, 1987·Biochimica Et Biophysica Acta·J L BockR K Gupta
Jun 19, 1990·Biochimica Et Biophysica Acta·M Kotb, N M Kredich
Jan 1, 1992·Archives of Biochemistry and Biophysics·E B Dubnova, A A Baykov
Sep 28, 2010·The Journal of Physical Chemistry. B·Christian BergmanRichard L Veech

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