PMID: 11345387May 10, 2001Paper

The effect of short-term prophylactic methylprednisolone on the incidence and severity of postpericardiotomy syndrome in children undergoing cardiac surgery with cardiopulmonary bypass

Journal of the American College of Cardiology
A R MottT F Feltes

Abstract

The aim of this study was to determine the effect of prophylactic immune suppression on the incidence and severity ofpostpericardiotomy syndrome (PPS) in children after cardiac surgery with cardiopulmonary bypass (CPB). Prophylactic suppression of the inflammatory response has an unknown effect on the incidence and severity of PPS in children undergoing surgery with CPB. This randomized double-blind placebo controlled trial included two study groups. Group A received pre-CPB intravenous methylprednisolone (1 mg/kg) plus four additional intravenous doses over 24 h, and Group B received intravenous saline placebo at identical intervals. Data included patient demographics, cardiac diagnosis/operation, CPB time, incidence and severity of PPS. Noncomplicated PPS--temperature >100.5 degrees F, pericardial friction rub, patient irritability, small pericardial +/- pleural effusion. Complicated PPS--noncomplicated PPS plus hospital readmission +/- pericardiocentesis or thoracentesis. We randomized 266 children: 20 exclusions (6 perioperative deaths, 14 reasons unrelated to treatment) leaving Group A (n = 126) and Group B (n = 120). There were no significant group differences in gender, cardiac diagnosis or CPB time. Group mean age diffe...Continue Reading

References

Feb 1, 1992·Clinical Cardiology·A H Khan
Mar 1, 1974·Circulation·M A EngleJ Zabriskie
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine·P J Barnes
Feb 1, 1993·Pacing and Clinical Electrophysiology : PACE·K S RovangS Mohiuddin
May 18, 1995·The New England Journal of Medicine·G P Chrousos
Dec 1, 1993·Annals of Internal Medicine·G P ChrousosM Karl
Apr 29, 1998·Critical Care Medicine·P E BollaertA Larcan
Jul 21, 1998·JAMA : the Journal of the American Medical Association·G U MeduriE A Tolley
Oct 1, 1953·Circulation·L A SOLOFFR P GLOVER
Mar 25, 1965·The New England Journal of Medicine·L M DRUSINM S SCHWARTZ

❮ Previous
Next ❯

Citations

Jun 11, 2002·Current Opinion in Pulmonary Medicine·Richard W Light
Mar 24, 2006·Southern Medical Journal·Dylan E Wessman, Christopher M Stafford
Mar 24, 2006·Southern Medical Journal·George Ritter
Apr 11, 2012·Current Opinion in Pulmonary Medicine·Massimo Imazio
Dec 1, 2008·International Journal of Evidence-based Healthcare·Suzi Robertson-Malt, Mahmoud El Barbary
Oct 13, 2014·The American Journal of Cardiology·M Chadi AlraiesBalaji K Tamarappoo
Sep 17, 2005·Intensive Care Medicine·Ignacio MalagonJames G Bovill
Mar 1, 2012·International Journal of Cardiology·Massimo ImazioYehuda Adler
Mar 24, 2016·Current Cardiology Reports·Alexander FardmanYehuda Adler
Nov 18, 2004·Journal of Pediatric Surgery·Tobias BerberichPeter M Jenny
Jun 1, 2011·The American Journal of Cardiology·Massimo ImazioYehuda Adler
May 13, 2015·American Heart Journal·Michael L O'ByrneAndrew C Glatz
Oct 9, 2012·International Journal of Cardiology·Massimo Imazio, Brian D Hoit
Jun 24, 2014·American Heart Journal·Jeroen J H BungeUNKNOWN Dexamethasone for Cardiac Surgery (DECS) Study Group
Oct 21, 2016·Current Cardiology Reports·Balaji K Tamarappoo, Allan L Klein
Apr 21, 2017·European Journal of Clinical Investigation·Dirk van OschJan M Dieleman
May 11, 2018·Expert Review of Cardiovascular Therapy·Rachel WamboldtAdrian Baranchuk
Jun 10, 2011·The Annals of Pharmacotherapy·Diana R MackDenise K Lowe
Oct 22, 2015·The Cochrane Database of Systematic Reviews·Mahmoud ElbarbarySuzanne Robertson-Malt
Jul 11, 2006·Current Opinion in Anaesthesiology·Christian F Stocker, Lara S Shekerdemian
Feb 24, 2006·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·József BocsiAttila Tárnok
Apr 25, 2012·Journal of Cardiovascular Medicine·Massimo ImazioYehuda Adler
Apr 22, 2020·Annals of Medicine·Joonas Lehto, Tuomas Kiviniemi
Jan 1, 2008·JBI Library of Systematic Reviews·Suzi Robertson-Malt, Mahmoud El Barbary
Dec 21, 2018·Journal of the American Heart Association·Gregory PattakosErnesto Jimenez
Dec 13, 2018·Pediatric Cardiology·Rik AdrichemArno A W Roest
Oct 13, 2020·The Cochrane Database of Systematic Reviews·Ben GibbisonBarnaby C Reeves
Dec 4, 2020·Heart & Lung : the Journal of Critical Care·Raffaele GiordanoMassimiliano Cantinotti
May 24, 2021·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Ali Fatehi HassanabadPaul Wm Fedak
Feb 29, 2020·The Journal of Thoracic and Cardiovascular Surgery·Joonas LehtoTuomas O Kiviniemi
Nov 6, 2021·Panminerva Medica·Matteo CasulaMassimo Imazio

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.