Abstract
Electrocardiographic repolarization abnormalities characterized by T-wave morphology parameters such as the principal component analysis ratio and the relative and the absolute T-wave residuum (TWR(rel) and TWR(abs)) are predictive of cardiovascular and/or all-cause mortality. However, when using a "10-second median beat" for analysis, the reported mean values for TWR(rel) vary widely and parameter reproducibility is somewhat suspect. In repeated electrocardiographic recordings conducted 1 month and 1 year apart on 15 and 27 healthy individuals, respectively, we studied the said T-wave morphology parameters in single complexes and in reduced noise signal averages containing 10 and 200 complexes. Considering all subjects, the mean (+/-SD) TWR(rel) was highest in a single complex (0.0345% +/- 0.0183%), intermediate in the 10-beat signal-averaged complexes (0.0125% +/- 0.0051%), and lowest in the 200-beat signal-averaged complexes (0.0078% +/- 0.0036%) (P < .0001), with the same trend also observed in the TWR(abs) but not in the principal component analysis ratio. Reproducibility as quantified by within-subject variance and reliability as quantified by the intraclass (intrasubject) correlation coefficient also improved as the numb...Continue Reading
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