The effect of sildenafil on gastric emptying in patients with end-stage renal failure and symptoms of gastroparesis

Clinical Pharmacology and Therapeutics
V DishyJ Weissgarten

Abstract

Delayed gastric emptying is a common disorder among patients with end-stage renal failure (ESRF). Pyloric relaxation, a major determinant of gastric emptying, is a nitric oxide (NO)-mediated process. NO-induced smooth muscle relaxation is mediated through its second messenger cyclic guanosine monophosphate, which is broken by tissue phosphodiesterases (PDEs). Thus the inhibition of cyclic guanosine monophosphate breakdown by PDE inhibitors can potentiate NO-mediated responses and facilitate pyloric relaxation. In an animal model of diabetes mellitus, treatment with sildenafil (a PDE-5 inhibitor) restored NO-mediated pyloric relaxation and improved gastric emptying. The aim of our study was to examine the hypothesis that sildenafil may improve gastric emptying in patients with ESRF and symptoms of gastric paresis. We studied 12 patients with ESRF (6 men; age range, 54-80 years; 5 with diabetic nephropathy; 4 +/- 1 years receiving long-term renal replacement therapy) after either placebo or a 25-mg tablet of sildenafil (Viagra; Pfizer Inc). Gastric emptying of a solid meal (one medium-sized fried egg mixed with 37 MBq [1 mCi] technetium Tc 99m phytate plus 1 slice of bread and 150 mL of water at the end of the meal) was assessed ...Continue Reading

Citations

Oct 15, 2005·Nature Clinical Practice. Gastroenterology & Hepatology·Christopher K Rayner, Michael Horowitz
Jul 8, 2010·Nature Reviews. Nephrology·Shayan Shirazian, Jai Radhakrishnan
Feb 3, 2006·The Journal of Clinical Investigation·Christopher K Rayner, Michael Horowitz
Jan 26, 2013·Journal of Neurogastroenterology and Motility·Jung Hwan Oh, Pankaj J Pasricha
Jan 1, 2012·Scientifica·Klaus Bielefeldt
Nov 1, 2005·Expert Opinion on Investigational Drugs·Brendan J R Whittle
Mar 4, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M ZandeckiJ Tack
Nov 26, 2014·Nature Reviews. Endocrinology·Liza K PhillipsMichael Horowitz
Jan 28, 2017·Expert Opinion on Investigational Drugs·Gareth J Sanger, Pankaj Jay Pasricha
Oct 24, 2007·Gastroenterology Clinics of North America·William L Hasler
Jun 2, 2007·Nature Clinical Practice. Gastroenterology & Hepatology·Harsha VittalPankaj J Pasricha
Nov 23, 2006·Current Diabetes Reports·Liza K PhillipsMichael Horowitz
Oct 13, 2005·Current Opinion in Gastroenterology·Jan Tack
Jun 6, 2009·Drugs·Jing MaMichael Horowitz
Apr 9, 2009·Expert Review of Gastroenterology & Hepatology·Joan KhooMichael Horowitz
Oct 29, 2015·Current Treatment Options in Gastroenterology·Xiaofeng Zhao, Hiroshi Mashimo
Sep 30, 2019·Gut·Madhusudan GroverVincenzo Stanghellini
Feb 1, 2013·Expert Review of Gastroenterology & Hepatology·Sony S ThazhathChristopher K Rayner
May 10, 2018·Scientific Reports·Yang Won MinPoong-Lyul Rhee
May 12, 2020·Gastroenterology·Michael Camilleri, Kenton M Sanders
Nov 1, 2021·Gastroenterology·Michael Camilleri, Kenton M Sanders

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