The effect of sildenafil on gastric motility and satiation in healthy controls

United European Gastroenterology Journal
F Carbone, J Tack

Abstract

Sildenafil induces relaxation of smooth muscle cells by blocking PDE5. Dyspepsia is one of sildenafil's most frequently reported adverse events, suggesting its effect on gastric motility. Our aim was to study the effect of sildenafil on gastric accommodation (GA) and gastric emptying (GE) in healthy volunteers (HVs). Sildenafil (50 mg) or placebo was randomly administered to 16 blinded HVs. After a manometry probe and an infusion catheter were positioned in the proximal stomach, the intragastric pressure (IGP) was measured before and during nutrient drink infusion (ND, 60 ml/min). HVs were asked to score their hunger, satiation and six epigastric symptoms at five-minute intervals. The experiment ended when the HVs scored maximal satiation during ND infusion at one-minute intervals. To assess GE, breath samples were collected every 15 minutes for six hours after the meal (244 kcal). ND infusion induced a drop in proximal stomach IGP, which was suppressed by sildenafil (average area under the curve for sildenafil: -33.6 ± 8.8 mmHg; placebo: -60.8 ± 11.3 mmHg, p = 0.005). Sildenafil-treated volunteers reached earlier maximal satiation compared to placebo (678 ± 70 ml vs. 836 ± 82.6 ml, p = 0.019). Finally, GE was significantly slo...Continue Reading

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Citations

Aug 27, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Florencia CarboneJan Tack
May 11, 2020·Current Obesity Reports·Dimitrios TsilingirisAlexander Kokkinos
Nov 22, 2019·Current Treatment Options in Rheumatology·Jessica Zhu, Tracy Frech
Feb 3, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Florencia CarboneJan Tack
Feb 23, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Florencia CarboneJan Tack
May 5, 2021·The American Journal of Gastroenterology·Emidio ScarpelliniJan Tack
Aug 15, 2021·Journal of Diabetes and Its Complications·R J JallehC K Rayner

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