The effect of silver nanoparticles on the reproductive system of adult male rats: A morphological, histological and DNA integrity study

Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University
Nasibeh FathiMaryam Bahmanzadeh

Abstract

Silver nanoparticles (AgNPs) are more often used in various products, and consequently the potential deleterious effects associated with exposure to them are of concern. Several lines of evidence have demonstrated that the toxicity of AgNPs affects different organs and leads to some side effects, including weight loss, inflammation and cell death. The aim of this study was to evaluate the effect of different concentrations of AgNPs on sperm parameters and testicular histology. In the present study, 28 male adult Wistar rats were categorized into a control group and 3 experimental groups (AgNP-1, AgNP-2 and AgNP-3), intraperitoneally (i.p.) receiving 30, 125 and 300 mg/kg of AgNPs, respectively. Twenty-eight days after injection the epididymes and the testes of each rat were dissected in order to evaluate sperm parameters, sperm chromatin integrity and histomorphometric changes in the testicular tissue. The results showed a significant decrease in sperm count (p < 0.0001), vitality (p < 0.05) and morphology changes (p < 0.001) in the group receiving 300 mg/kg of AgNPs compared to the control group. A significant decrease was also observed in the number of spermatogonia, Sertoli and Leydig cells in the AgNP-2 and AgNP-3 groups (p...Continue Reading

Citations

Jun 13, 2020·Nanotoxicology·Juliana Lis Mendes de BritoCarolina Madeira Lucci
Mar 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Janet Olayemi OlugbodiFanyana Mtunzi
Feb 1, 2019·Metabolic Brain Disease·Rodrigo Rodrigues da ConceiçãoGisele Giannocco
Mar 7, 2021·International Journal of Environmental Research and Public Health·Mehwish IftikharTiziana Cappello
Mar 20, 2021·The Science of the Total Environment·Maingredy Rodrigues SouzaThiago Lopes Rocha
Apr 10, 2021·International Journal of Nanomedicine·Asmaa M ShehataPeter A Noshy
Aug 24, 2021·Environmental Science and Pollution Research International·Meenu SinghSuresh Vir Singh Rana

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