PMID: 36456Apr 1, 1979

The effect of simultaneous administration of 3,4-dihydroxyphenylpyruvic acid and L-dopa on the bioavailability of L-dopa in rat and mouse

The Journal of Pharmacy and Pharmacology
P HietalaN Grönfors


In the rat, administration of 3-(3,4-dihydroxy)-L-phenylalanine (L-dopa) simultaneously with the corresponding alpha-keto acid, 3,4-dihydroxyphenylpyruvic acid (DHPPA), gives significantly higher concentrations of L-dopa in the serum and of dopamine and homovanillic acid in the brain than the same dose of L-dopa alone. Correspondingly, DHPPA potentiates the effect of L-dopa on the locomotor activity in reserpine-treated mice. DHPPA is postulated to increase the absorption of intact L-dopa from the gut by preventing the transamination reaction between L-dopa and the physiological alpha-keto acids.


Oct 18, 2006·Clinical and Experimental Pharmacology & Physiology·Mei WuYong-Xiang Wang
Sep 6, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Nelida FernandezJuan J Garcia
Nov 1, 1982·Acta Pharmacologica Et Toxicologica·I B Lindén, S Niemi
Sep 1, 1982·Acta Pharmacologica Et Toxicologica·I B LindénH Vapaatalo


Jun 1, 1976·Journal of Pharmaceutical Sciences·S CotlerS A Kaplan
Jan 15, 1976·Biochemical Pharmacology·J H FellmanT S Fujita
May 1, 1969·The Journal of Pharmacy and Pharmacology·G BartholiniA Pletscher
May 30, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·F Geissbuehler
Mar 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·G CurzonJ Trigwell
Dec 1, 1964·International Journal of Neuropharmacology·C C CHANG

Related Concepts

Homovanillic Acid
Keto Acids
Phenylpyruvic Acids
Dopamine Measurement
Brain Chemistry
Drug Interactions

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