The effect of simvastatin on serum cytokine levels and bone metabolism in postmenopausal subjects: negative correlation between TNF-alpha and anabolic bone parameters

Journal of Bone and Mineral Metabolism
Canan TikizCiğdem Tüzün

Abstract

In this prospective study, we aimed to evaluate the effect of simvastatin on bone metabolism and the correlation between changes in bone turnover parameters and serum cytokine levels. For this purpose, 38 postmenopausal subjects with hypercholesterolemia (>240 mg/dl), not on osteoporosis treatment, were studied. Simvastatin was started at a dose of 20 mg daily and continued for 3 months. Six patients were excluded from the study during the follow-up period. Pre- and post-treatment samples were analyzed for bone alkaline phosphatase (BAP) and osteocalcin (OCL), as markers of bone formation; for carboxyterminal telopeptide of collagen I (CTX), as a marker of bone resorption; and for interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) cytokine levels. Total cholesterol level was decreased from 262.1 +/- 30.9 to 210.2 +/- 35.6 mg/dl after simvastatin treatment (P < 0.0001). While no significant change was observed in serum CTX level, BAP and OCL levels were significantly increased (from 120.8 +/- 56.6 to 149.5 +/- 57.6 IU/l [P = 0.008], and from 20.8 +/- 12.6 to 34.7 +/- 18.4 microg/l [P = 0.015], respectively). In the analysis of cytokines, while no significant change was observed in IL-6 levels, the TNF-alpha level w...Continue Reading

Citations

Feb 20, 2009·Menopause : the Journal of the North American Menopause Society·Jung Gu KimYoung Min Choi
May 18, 2010·Menopause : the Journal of the North American Menopause Society·Jirong YueMing Yang
Nov 28, 2012·Journal of Periodontology·Roberta DalcicoGerly A de C Brito
Oct 9, 2012·Journal of Dietary Supplements·Hassan Mozaffari-KhosraviMohammad Hossein Fllahzadeh
Aug 16, 2006·The American Journal of the Medical Sciences·Manfredi Rizzo, Giovam Battista Rini
Nov 23, 2011·Pharmacological Reviews·Patrizia GazzerroMaurizio Bifulco
Aug 30, 2007·The Journal of Clinical Endocrinology and Metabolism·Henry G BoneMichael R McClung
Feb 14, 2006·The American Journal of Clinical Nutrition·Gregory R Mundy

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