The effect of single agent oral fusaric acid (FA) on the growth of subcutaneously xenografted SCC-1 cells in a nude mouse model

Investigational New Drugs
James M RudaBrendan C Stack

Abstract

To determine whether oral administration of fusaric acid (FA) inhibits tumor growth in an animal model of head and neck cancer (HNSCC). In vivo murine model, two arm controlled study. Thirty-eight (38) 5-week-old athymic nude mice were randomly assigned to a fusaric acid treatment group (1 mg/mL) (n = 19) or a sterile saline group (n = 19). A left, lateral flank subcutaneous injection of 2.0 x 10(6) UM-SCC-1 cells were administered to all mice on day 1. Both groups were gavaged daily with either 0.25 mLs of oral FA or sterile saline throughout the experiment (32 days). Latency to a measurable tumor (> or =65 mm3), and tumor volumes were recorded after tumor xenografting. Tumor weights were recorded at the conclusion of the experiment. Tumor volume growth curves were modeled as polynomial functions of time with treatment interaction effects. Survivorship functions for time to measurable tumor were estimated using the Kaplan-Meier product limit estimator. Survival analysis showed mice treated with FA developed measurable tumors after a significantly longer interval post-xenografting than control mice (p = 0.00451). By Day 9, all mice in the control group had developed measurable tumors in comparison to only 78% of mice in the FA ...Continue Reading

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Citations

Jun 7, 2014·Drugs in R&D·Brendan C StackHoward P Hendrickson
Jul 29, 2011·International Journal of Cancer. Journal International Du Cancer·Zhong-Yin YangQin-Long Gu
Jul 9, 2016·Toxicon : Official Journal of the International Society on Toxinology·Naeem Sheik AbdulAnil A Chuturgoon
Sep 8, 2016·Journal of Agricultural and Food Chemistry·Christiane Gruber-DorningerFranz Berthiller
Dec 14, 2016·Toxicon : Official Journal of the International Society on Toxinology·Nikita DevnarainAnil A Chuturgoon
Sep 12, 2018·Drug and Chemical Toxicology·Sevcan MamurDeniz Yüzbaşıoğlu
Jan 25, 2013·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Sannaningaiah DevarajaKempaiah Kemparaju

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