The effect of six months of elastic band resistance training, nutritional supplementation or cognitive training on chromosomal damage in institutionalized elderly

Experimental Gerontology
Bernhard FranzkeVienna Active Ageing Study Group (VAAS)

Abstract

Increased DNA and chromosomal damage are linked to aging and age-related diseases like cardiovascular diseases, diabetes or cancer. Physical activity and an optimal status of micro- and macronutrients are known to reduce the incidence of MN, a marker for chromosomal instability and mutagenicity. Once older people reach a certain age they change from a home-living situation to an institutionalized situation, which is often accompanied by malnutrition, depression and inactivity. We conducted the current study to investigate the effect of a six month progressive resistance training (RT), with or without protein and vitamin supplementation (RTS) or cognitive training (CT) only, on chromosomal damage measured by the cytokinesis block micronucleus cytome assay in 97 Austrian institutionalized women and men (65-98years). All three intervention groups demonstrated a tendency of a reduced frequency of cells with MN (-15%) as well as for the total number of MN (-20%), however no significant time-effect was observed. Besides a significant increase in plasma B12 and red blood cell folate status, the six month change of B12 was negatively correlated with the six month change of the MN frequency in the RTS group (r=-0.584, p=0.009). Our resu...Continue Reading

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Citations

Nov 26, 2015·Mutation Research. Reviews in Mutation Research·Bernhard FranzkeKarl-Heinz Wagner
Sep 28, 2016·Journal of the American Medical Directors Association·Danielle K ThomasCarolyn A Greig
Mar 14, 2018·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Jociane SchardongRodrigo Della Méa Plentz
Jun 12, 2018·Frontiers in Endocrinology·Alexandre Rebelo-MarquesJoão Espregueira-Mendes
Jan 30, 2021·ELife·Matt YousefzadehLaura Niedernhofer

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