The effect of Smallanthus sonchifolius leaf extracts on rat hepatic metabolism

Cell Biology and Toxicology
K ValentováJitka Ulrichová

Abstract

Smallanthus sonchifolius (yacon), originating from South America, has become popular in Japan and in New Zealand for its tubers which contain beta-1,2-oligofructans as the main saccharides. The plant is also successfully cultivated in Central Europe in the Czech Republic in particular. Its aerial part is used in Japan and in Brazil as a component in medicinal teas; while aqueous leaf extracts have been studied for their hypoglycemic activity in normal and diabetic rats. We have already demonstrated the high content of phenolic compounds in yacon leaf extracts and their in vitro antioxidant activity. In this paper, we present the effects of two organic fractions and two aqueous extracts from the leaves of S. sonchifolius on rat hepatocyte viability, on oxidative damage induced by tert-butyl hydroperoxide (t-BH) and allyl alcohol (AA), and on glucose metabolism and their insulin-like effect on the expression of cytochrome P450 (CYP) mRNA. All the extracts tested exhibited strong protective effect against oxidative damage to rat hepatocyte primary cultures in concentrations ranging from 1 to 1000 microg/ml, reduced hepatic glucose production via gluconeogenesis and glycogenolysis at 1000 microg/ml. Moreover, the effects of the org...Continue Reading

Citations

Mar 11, 2006·Cell Biology and Toxicology·K ValentováV Simánek
Oct 29, 2010·Natural Product Research·Dennis D RagaConsolacion Y Ragasa
Dec 7, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Katerina ValentováVilím Simánek
Oct 19, 2010·Journal of Ethnopharmacology·Rejane Barbosa de OliveiraFernando Batista Da Costa
Sep 4, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Naira J N BritoMaria das Graças Almeida
Apr 2, 2010·Allergy, Asthma & Immunology Research·Eun Young YunYi Yeong Jeong
Jun 11, 2014·Critical Reviews in Food Science and Nutrition·Hudsara Aparecida de Almeida PaulaCélia Lúcia de Luces Fortes Ferreira
Aug 16, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Klinsmann Carolo Dos SantosCamila Renata Corrêa
Nov 12, 2017·International Journal of Biological Macromolecules·Larry L R ParedesGuilherme L Sassaki
Aug 25, 2007·Journal of Agricultural and Food Chemistry·Katerina ValentováJitka Ulrichová
Feb 16, 2006·Journal of Agricultural and Food Chemistry·Katerina ValentováJitka Ulrichová
Jul 7, 2005·Journal of Agricultural and Food Chemistry·Katerina ValentováJitka Ulrichová

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