The effect of smoking on peripheral insulin sensitivity and plasma endothelin level

Diabetes & Metabolism
A M BorissovaS Krivoshiev

Abstract

The aim of the present study was to investigate the effect of smoking on peripheral insulin effectiveness. Seven healthy volunteers, nonsmokers, of mean age 39.6 +/- 7.1 Years and mean BMI 22.65 +/- 11.98 kg/m2, without family history of diabetes mellitus, with normal blood pressure participated in the study. All the parameters were studied twice - at baseline as well as after smoking (4 cigarettes per one hour). The study was performed in three days: at the first day we studied peripheral insulin effectiveness (M) in vivo by the artificial endocrine pancreas (Biostator), using the euglycaemic hyperinsulinaemic clamp technique, and insulin-receptor binding on circulating mononuclear blood cells; at the second day - the same parameters after one-hour smoking during the third hour of clamping; at the third day - plasma endothelin level, blood pressure and heart rate at baseline and after one-hour smoking. There was a significant decrease in glucose utilization during the second clamp test, when the volunteers smoked during the third hour as compared to the test at baseline (p=0.04). This was accompanied by a significant decrease in insulin receptor affinity (p=0.04). Systolic blood pressure and heart rate increased significantly ...Continue Reading

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Citations

Nov 22, 2007·Diseases of the Colon and Rectum·Sung-Wook OhSang Goon Shim
Jun 26, 2013·Meditsinskaia tekhnika·N A BazaevK V Pozhar
Apr 21, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroaki KawanoHisao Ogawa
Mar 27, 2012·International Journal of Oncology·Uwe A WittelSurinder K Batra
Mar 22, 2018·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Mariola Śliwińska-MossońHalina Milnerowicz
Jun 23, 2006·The American Journal of Gastroenterology·Paul J LimburgJames R Cerhan
Oct 2, 2014·American Journal of Physiology. Endocrinology and Metabolism·Mikayla O ThatcherBenjamin T Bikman
Sep 10, 2014·Applied Immunohistochemistry & Molecular Morphology : AIMM·Mariola Sliwińska-MossońHalina Milnerowicz
Apr 11, 2017·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Mariola Śliwińska-Mossoń, Halina Milnerowicz
Sep 29, 2020·Pharmacology & Therapeutics·Patricia Seoane-CollazoMiguel López
Jul 3, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mabel GuevaraJosé M Alvarez-Suarez
Jan 1, 2014·Diabetology & Metabolic Syndrome·Omar JamalKhurram Nasir

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