Apr 1, 1978

The effect of sodium 5,6-dimethyl-2-nitroindanedione on anaphylactic reactions in vitro

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T J SharpeB A Spicer

Abstract

A nitroindanedione (BRL 10833) inhibited the antigen induced release of histamine and slow reacting substance of anaphylaxis (SRS-A) from passively sensitized human lung at similar concentrations to those required for the inhibition of histamine release by disodium cromoglycate (DSCG). BRL 10833 was more potent than DSCG as an inhibitor of histamine release by antigen from actively and passively sensitized rat peritoneal cells and rat skin fragments.

Mentioned in this Paper

Vicrom
Lung
Passive Cutaneous Anaphylaxis
Indanones
Leukocytes
Antigens
Anaphylaxis
Skin
Histamine Release
SRS-A

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Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.