PMID: 8951677Jan 1, 1996Paper

The effect of sodium hyaluronate on the growth of rabbit corneal epithelial cells in vitro

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
T MiyazakiK Horie

Abstract

The effect of sodium hyaluronate (Na-HA) on the growth of rabbit corneal epithelial cells was investigated in vitro by using MTT assay and [3H]-thymidine incorporation. Na-HA, with a molecular weight of 86 x 10(4), enhanced the growth of the corneal epithelial cells cultured on a fibronectin (FN) coated dish, but when cells were cultured on a noncoated dish, Na-HA did not enhance the growth of the cells. Na-HA, labeled with 5-aminofluorescein (FA-HA), bound to the corneal epithelial cells, and the CD44-like molecule was identified on the cells by using a monoclonal antibody, OS/37. Furthermore, the binding of FA-HA to the cells was significantly inhibited by the monoclonal antibody. These results suggest that Na-HA binds to the CD44-like molecule associated with FN and then enhances the growth of the corneal epithelial cells.

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Citations

Jun 21, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Françoise BrignoleChristophe Baudouin
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Apr 28, 2004·The Veterinary Clinics of North America. Small Animal Practice·Ellison Bentley, Christopher J Murphy
Mar 24, 2004·Critical Reviews in Oncology/hematology·Yanusz Wegrowski, Francois-Xavier Maquart
Apr 29, 2005·Journal of the European Academy of Dermatology and Venereology : JEADV·M B Brown, S A Jones
Dec 8, 2007·Korean Journal of Ophthalmology : KJO·Jun Woong MoonMee Kum Kim
Aug 4, 2009·Analytical and Bioanalytical Chemistry·Ji Hye KwonMyeong Hee Moon
May 11, 2019·Expert Opinion on Drug Delivery·Dmitri A Ossipov
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