PMID: 6107988Jan 1, 1980Paper

The effect of somatostatin on serum group I pepsinogens (PG I), serum gastrin, and gastric H+ and pepsin secretion in man

Scandinavian Journal of Gastroenterology
H Waldum, P G Burhol

Abstract

Six healthy young males were studied with an intravenous infusion of saline for 1 h, followed by somatostatin, 100 microgram/h, for 2 h, and thereafter by another 2 h with saline infusion. Gastric H+ and pepsin outputs were determined in 30-min periods throughout the study. Blood was drawn at regular intervals, and blood glucose was determined by a hexokinase method. PG I and gastrin in serum were determined by radioimmunoassay methods. Gastric H+ and pepsin outputs were markedly reduced during the somatostatin infusion and the first 30-min period after cessation of the somatostatin infusion. In the subsequent 60-min period gastric pepsin secretion increased significantly as compared with the basal period, whereas the gastric H+ output only increased non-significantly. Mean serum PG I increased during the somatostatin infusion and remained elevated throughout the study. The rise in serum PG I was marked in five and only marginal in the sixth person. Serum gastrin fell during the somatostation infusion and returned to the basal level thereafter. Blood glucose, on the other hand, fell only during the first 90 min of somatostatin infusion, and then climbed to the basal level, where it stayed for the remaining part of the study. Th...Continue Reading

References

Jan 1, 1977·Scandinavian Journal of Gastroenterology·L E HanssenJ Myren
Jan 1, 1979·Scandinavian Journal of Gastroenterology·H L WaldumB K Straume
Jan 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R S SherwinP Felic
Jan 1, 1977·Scandinavian Journal of Gastroenterology·M H VatnJ Myren
Sep 1, 1978·Metabolism: Clinical and Experimental·W Creutzfeldt, R Arnold
Jan 1, 1979·Scandinavian Journal of Gastroenterology·H L WaldumP G Burhol
Oct 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·J F RehfeldB Rubin
Jan 1, 1972·Scandinavian Journal of Gastroenterology·E Schrumpf, T Sand

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Citations

Sep 1, 1984·Postgraduate Medical Journal·D F Levine, M Beer
Jan 1, 1981·Scandinavian Journal of Gastroenterology·H L Waldum, P G Burhol
Mar 1, 1987·Scandinavian Journal of Gastroenterology·P M KlevelandP Sandberg
Mar 1, 1982·Scandinavian Journal of Gastroenterology·H L WaldumP Gunnes
Nov 28, 2013·Acta Physiologica·H L WaldumR Fossmark
Dec 8, 2010·Scandinavian Journal of Gastroenterology·Constantin S JianuHelge L Waldum

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