The effect of somatostatin on the response of GLI to the intraduodenal administration of glucose, protein, and fat.

Diabetologia
H SakuraiR H Unger

Abstract

The effects of somatostatin on GLI release during the absorption of intraduodenally administered glucose, casein hydrolysate and longchain triglycerides were studied in conscious dogs. Whereas, after an intraduodenal glucose load, GLI rose promptly in saline-infused control experiments to a peak of 5 ng/ml (SEM +/- 4) in 60 minutes, significantly lower values were observed during somatostatin infusion (P less than 0.025 -- 0.05). A similar reduction in the magnitude of the GLI response to intraduodenally administered casein hydrolysate (P less than 0.05) and fat (p less than 0.05) was observed.

References

Jul 1, 1975·The Journal of Clinical Investigation·H SasakiR H Unger
Dec 8, 1973·Lancet·K G AlbertiH Orskov
May 1, 1974·The Journal of Clinical Endocrinology and Metabolism·T M SilerR Guillemin
Aug 24, 1965·Biochimica Et Biophysica Acta·A Mühlrad, G Hegyi
Dec 1, 1974·The Journal of Clinical Investigation·H SakuraiR H Unger
Apr 26, 1974·Science·D J KoerkerC C Gale
Oct 1, 1973·The Journal of Clinical Investigation·I BöttgerR H Unger
Oct 1, 1973·The Journal of Clinical Endocrinology and Metabolism·T M SilerR Guillemin
May 1, 1974·The Journal of Clinical Endocrinology and Metabolism·G W DeVaneS S Yen
Jul 16, 1970·The New England Journal of Medicine·W A MüllerR H Unger
Sep 1, 1970·Diabetes·I ValverdeR H Unger
Apr 1, 1972·The Journal of Clinical Investigation·I BöttgerR H Unger
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·V HerbertS J Bleicher
Mar 1, 1957·Archives of Biochemistry and Biophysics·H ROSEN
Jul 1, 1960·The Journal of Clinical Investigation·R S YALOW, S A BERSON

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Citations

Jan 1, 1981·Diabetologia·R H Unger
Jan 14, 1978·Diabetologia·R LuftT Hökfelt
Jan 1, 1980·Acta diabetologica latina·S ItoY Matsubara
Jul 7, 2012·Current Diabetes Reports·Claire M Issa, Sami T Azar
Oct 1, 1983·Journal of the Autonomic Nervous System·D Novin
Jan 1, 1985·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M P López-RuizJ C Prieto
Nov 18, 2000·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·A S BabaP J Buttery
Aug 9, 1979·The New England Journal of Medicine·G J KrejsR H Unger
Oct 1, 1978·British Journal of Pharmacology·W G Linscheer, K L Raheja
Nov 1, 1983·Clinics in Endocrinology and Metabolism·J A Wass
Nov 1, 1983·American Journal of Surgery·S SakazakiK Yamaguchi
Apr 1, 1981·Metabolism: Clinical and Experimental·D J Koerker, B C Hansen
Aug 1, 1979·Metabolism: Clinical and Experimental·D J GoldbergR S Sherwin
Mar 1, 1987·Diabetes Research and Clinical Practice·A Ohneda
Jul 1, 1977·FEBS Letters·V SchusdziarraR H Unger
Dec 22, 1999·Endocrine Reviews·T J Kieffer, J F Habener
Jan 1, 1979·Archives of Virology·K G NicholsonP Harrison
Jan 1, 1978·Scandinavian Journal of Gastroenterology·L KayassehJ Girard
Jan 1, 1978·Scandinavian Journal of Gastroenterology·C JohanssonR Luft

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