PMID: 6843786Jan 1, 1983

The effect of some decarboxylase inhibitors on striatal tyramines in the mouse

A V Juorio


The administration of carbidopa (5-50 mg/kg), a peripheral L-aromatic aminoacid decarboxylase inhibitor, significantly increased striatal tyramines; maximal effects were observed at 2-4 hr after treatment. Benserazide produced similar effects. The drug, NSD 1034, that inhibits both central and peripheral decarboxylase, produced a dose-dependent reduction in striatal p-tyramine; in contrast, concentrations of m-tyramine were increased by the smaller doses (2-20 mg/kg) and reduced by the larger dose (400 mg/kg). The results support the view that the tyramines are formed within the brain by decarboxylation of their parent aminoacids but by different mechanisms.


Jan 1, 1975·Canadian Journal of Biochemistry·S R PhilipsA A Boulton
Oct 10, 1975·Brain Research·A A BoultonP H Wu
May 1, 1974·Canadian Journal of Biochemistry·S R PhilipsA A Boulton
Jan 1, 1950·Biochimica Et Biophysica Acta·H BLASHCKO

Related Concepts

NSD 1034 phosphate
Ro 4-4602
Carbidopa, (S)-Isomer
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