The effect of source animal age upon the in vivo remodeling characteristics of an extracellular matrix scaffold.

Biomaterials
Brian M SicariStephen F Badylak

Abstract

Biologic scaffolds composed of mammalian extracellular matrix (ECM) are routinely used for the repair and reconstruction of injured or missing tissues in a variety of pre-clinical and clinical applications. However, the structural and functional outcomes have varied considerably. An important variable of xenogeneic biologic scaffolds is the age of the animal from which the ECM is derived. The present study compared the in vivo host response and remodeling outcomes of biologic scaffolds composed of small intestinal submucosa (SIS)-ECM harvested from pigs that differed only in age. Results showed that there are distinct differences in the remodeling characteristics as a consequence of source animal age. Scaffolds derived from younger animals were associated with a more constructive, site appropriate, tissue remodeling response than scaffolds derived from older animals. Furthermore, the constructive remodeling response was associated with a dominant M2 macrophage response.

References

Mar 23, 1979·Virchows Archiv. A, Pathological Anatomy and Histology·U Rowlatt
Jan 1, 1997·The International Journal of Biochemistry & Cell Biology·D C WestM T Longaker
Jul 22, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A J CowinM W Ferguson
Nov 22, 2001·The Journal of Biological Chemistry·Bryan P TooleMarkku I Tammi
Nov 9, 2004·Trends in Immunology·Alberto MantovaniMassimo Locati
Mar 1, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·M H ZhengD Wood
Oct 11, 2005·Clinics in Podiatric Medicine and Surgery·Patrick G De Deyne, Stephanie M Kladakis
Mar 7, 2006·Journal of Shoulder and Elbow Surgery·Charalampos G ZalavrasJames Tibone
Apr 4, 2006·Tissue Engineering·Bryan BrownStephen F Badylak
May 2, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Thore ZantopStephen F Badylak
Jul 18, 2006·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Julie E AdamsScott P Steinmann
Nov 28, 2006·The Annals of Thoracic Surgery·Alejandro NieponiceStephen F Badylak
Apr 4, 2007·The Journal of Bone and Joint Surgery. American Volume·Judie R WaltonGeorge A C Murrell
May 26, 2007·Biomaterials·Stephen F Badylak
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Fernando Oneissi MartinezMassimo Locati
May 27, 2008·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Payam AkhyariArtur Lichtenberg
Jun 10, 2008·Advances in Physiology Education·Satheesha Nayak B, David W Rodenbaugh
Jul 29, 2008·Gastrointestinal Endoscopy·Alejandro NieponiceStephen F Badylak
Oct 8, 2008·Tissue Engineering. Part a·Allison J BeattieStephen F Badylak
Oct 28, 2008·Tissue Engineering. Part a·Stephen F BadylakAnn M Stewart-Akers
Jan 8, 2009·Tissue Engineering. Part a·Jolene E ValentinStephen F Badylak
Jan 24, 2009·Nature Reviews. Cancer·Darci T ButcherValerie M Weaver
Apr 2, 2009·Artificial Organs·Thorsten DoedeMatthias Goernig
Dec 8, 2009·Proceedings of the National Academy of Sciences of the United States of America·Vineet AgrawalStephen F Badylak
Mar 12, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·James G Tidball, S Armando Villalta
May 19, 2010·Developmental Biology·Sarah CalveHans-Georg Simon
Jul 20, 2010·Biomaterials·Jolene E ValentinStephen F Badylak
Sep 28, 2010·Biomaterials·Stephen TotteyStephen F Badylak
Dec 6, 2011·Biomaterials·Timothy J KeaneStephen F Badylak

❮ Previous
Next ❯

Citations

Sep 10, 2013·Cellular & Molecular Immunology·Joseph K AntoniosStuart B Goodman
Dec 1, 2012·Physical Biology·Kandice Tanner
Dec 12, 2012·Tissue Engineering. Part B, Reviews·Birgit AndréeAndres Hilfiker
Oct 29, 2013·Tissue Engineering. Part a·Bernard GrevemeyerBryan N Brown
May 3, 2014·Science Translational Medicine·Brian M SicariStephen F Badylak
Dec 3, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Brian M SicariStephen F Badylak
Jul 22, 2014·Journal of Cutaneous Pathology·William R MundayChristine Ko
Mar 29, 2014·Journal of Tissue Engineering and Regenerative Medicine·Timothy J Keane, Stephen F Badylak
Jul 22, 2014·Biomaterials·Brian M SicariStephen F Badylak
Jul 22, 2014·Biomaterials·Denver M FaulkStephen F Badylak
Mar 31, 2015·Tissue Engineering. Part B, Reviews·Ricardo Londono, Stephen F Badylak
Oct 9, 2014·BioMed Research International·Katie H SizelandRichard G Haverkamp
Sep 13, 2014·Annals of Biomedical Engineering·Ricardo Londono, Stephen F Badylak
Jun 10, 2014·Frontiers in Physiology·Claudia FuocoCesare Gargioli
Mar 19, 2014·Biomaterials Science·Todd D JohnsonKaren L Christman
May 24, 2016·Neural Regeneration Research·Yolandi van der Merwe, Michael B Steketee
Sep 8, 2016·Journal of Biomedical Materials Research. Part a·Jenna L DzikiStephen F Badylak
Oct 28, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Timothy J KeaneStephen F Badylak
Jan 29, 2017·Journal of Biomedical Materials Research. Part a·Daniel HachimBryan N Brown
Mar 16, 2017·Journal of Biomedical Materials Research. Part a·Jing-Kun ZhangYan-Fang Xu
May 2, 2017·Tissue Engineering. Part a·Jenna L DzikiStephen F Badylak
Jul 13, 2017·Nature Reviews. Gastroenterology & Hepatology·George S HusseyStephen F Badylak
Oct 7, 2017·Journal of Biomedical Materials Research. Part a·Jie-Liang YangTing-Wu Qin
Nov 25, 2017·Neural Regeneration Research·Yolandi van der MerweMichael B Steketee
Aug 30, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Neill J TurnerStephen F Badylak
Jul 8, 2016·Science Advances·Luai HuleihelStephen F Badylak
Nov 13, 2013·Expert Review of Cardiovascular Therapy·Juan C ChachquesCarlos Semino
Mar 23, 2017·Cold Spring Harbor Perspectives in Medicine·Alessandra CostaStephen F Badylak
Aug 10, 2019·Stem Cells International·Junio DortNicolas A Dumont
Aug 23, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Guangxiu CaoXiaoming Li
May 25, 2018·Innovative Surgical Sciences·Frank-Mattias Schäfer, Maximilian Stehr
Nov 20, 2019·Annals of Biomedical Engineering·Madeline C Cramer, Stephen F Badylak
Dec 25, 2015·Tissue Engineering. Part B, Reviews·Katherine WilesMartin A Birchall
Oct 28, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Brian M SicariStephen F Badylak
Oct 6, 2020·Tissue Engineering. Part C, Methods·Lina M QuijanoStephen F Badylak

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.