The effect of soy isoflavones on arterial stiffness: a systematic review and meta-analysis of randomized controlled trials.

European Journal of Nutrition
Brian ManAkira Sekikawa

Abstract

Some but not all randomized controlled trials (RCTs) of soy isoflavones showed their beneficial effect on arterial stiffness, a predictor of cardiovascular events, dementia, and all-cause mortality, independent of traditional risk factors. To test the hypothesis that supplementation of soy isoflavones reduces arterial stiffness, we performed a systematic review and meta-analysis of RCTs of soy isoflavones on arterial stiffness. The protocol of this systematic review was registered with PROSPERO (CRD42019126128) and written in accordance with PRISMA. The PubMed, Embase, and clinicaltrials.gov databases were searched using the following criteria: human subjects, soy isoflavones as intervention, and arterial stiffness as primary outcome. A random-effects meta-analysis was used to pool estimates across studies. Standardized mean difference (SMD) was used to synthesize quantitative results. Among 998 articles retrieved, 8 articles met our criteria. Duration of intervention was relatively short (maximum of 12 weeks). Outcome measurements extracted were pulse wave velocity (PWV), systemic arterial compliance (SAC), augmentation index (AI), and cardio-ankle vascular index (CAVI). Soy isoflavones reduced arterial stiffness compared to p...Continue Reading

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Citations

Dec 23, 2020·Nutrients·Saioa Gómez-ZoritaMaría Puy Portillo
Apr 4, 2021·Animals : an Open Access Journal From MDPI·Ludmila KřížováTomáš Kašparovský
Aug 17, 2021·Heart, Lung & Circulation·Ioana MozosConstantin Tudor Luca

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