The effect of spatially inhomogeneous extracellular electric fields on neurons.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Costas A AnastassiouChristof Koch

Abstract

The cooperative action of neurons and glia generates electrical fields, but their effect on individual neurons via ephaptic interactions is mostly unknown. Here, we analyze the impact of spatially inhomogeneous electric fields on the membrane potential, the induced membrane field, and the induced current source density of one-dimensional cables as well as morphologically realistic neurons and discuss how the features of the extracellular field affect these quantities. We show through simulations that endogenous fields, associated with hippocampal theta and sharp waves, can greatly affect spike timing. These findings imply that local electric fields, generated by the cooperative action of brain cells, can influence the timing of neural activity.

Citations

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Apr 13, 2011·Medical & Biological Engineering & Computing·Sara L Gonzalez AndinoRolando Grave de Peralta Menendez
Oct 11, 2012·ACS Chemical Neuroscience·Gerard Marx, Chaim Gilon
Jan 18, 2011·Nature Neuroscience·Costas A AnastassiouChristof Koch
Jun 10, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David SullivanGyörgy Buzsáki
Nov 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Davide ReatoLucas C Parra
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