PMID: 6975209Aug 1, 1981Paper

The effect of splenectomy on the appearance of specific antibody-forming cells in lungs of dogs after intravenous immunization with sheep erythrocytes

Experimental Lung Research
H B KaltreiderC Pellegrini

Abstract

Effector cells of both T-lymphocyte-mediated and B-lymphocyte-mediated immunity can be induced experimentally to appear in the lung. It is not known whether such effector lymphocytes arise from precursor cells resident in the lung or if they are recruited from systemic sources. Previous studies demonstrated that IV administration of sheep erythrocytes to dogs consistently resulted in the appearance of specific antibody-forming cells, B-cell effectors, in lavage preparations obtained from the lung. In the present study, experiments were performed to determine the mechanism of appearance of effector B-cells in the lung after IV immunization. Control, sham-operated, and splenectomized dogs were immunized IV with 10(10) sheep erythrocytes. The concentrations of antibody-forming cells appearing in lymphocytes obtained from the lung and from peripheral blood were measured during both the primary and the secondary immune responses. Control and sham-operated dogs developed high concentrations of antibody-forming cells in blood 5 days after immunization, but splenectomized dogs did not. Antibody-forming cells consistently appeared in substantial numbers in lymphocytes obtained by lavage from lungs of control and sham-operated animals, h...Continue Reading

Citations

Sep 1, 1988·The American Review of Respiratory Disease·D E Bice, B A Muggenburg
Mar 24, 2007·American Journal of Respiratory and Critical Care Medicine·Anagha P PhadkeBorna Mehrad
Jan 1, 1988·Experimental Lung Research·D E Bice, G M Shopp
Apr 23, 2009·Australian Veterinary Journal·Ni ChristensenKl Bosward
Jan 6, 2004·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Thomas TschernigReinhard Pabst
Oct 31, 2007·Clinics in Chest Medicine·Rohit Katial, Weihong Zheng

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