The effect of spontaneous changes in urinary pH on mexiletine plasma concentrations and excretion during chronic administration to healthy volunteers

British Journal of Clinical Pharmacology
A JohnstonN A Hamer

Abstract

1. The effect of spontaneous changes in urinary pH on renal excretion and plasma concentration of mexiletine has been examined during chronic administration of subtherapeutic doses of the drug to healthy volunteers. 2. Significant correlations were found between urinary pH and the plasma concentration and renal excretion of mexiletine. 3. Prediction of plasma mexiletine concentrations from our data suggests that the amount of mexiletine in plasma would increase by more than 50% following a rise in urinary pH similar to that which occurred spontaneously in our subjects. 4. Factors which influence urinary pH should be considered when the dosage of mexiletine is chosen. Extremes of urinary pH may account for some cases of inefficacy of the drug, and for the occurrence of unwanted effects at conventional doses.

References

Jan 1, 1993·European Journal of Clinical Pharmacology·P LledóP Turner
Jan 1, 1986·European Journal of Clinical Pharmacology·P J PentikäinenL M Lampinen
Oct 1, 1991·British Journal of Clinical Pharmacology·F BrolyM Lhermitte
Dec 1, 1980·American Heart Journal·R A Ronfeld
May 1, 1984·American Heart Journal·R L WoosleyD Roden
Feb 27, 1984·The American Journal of Cardiology·G J Conard, R E Ober
Sep 1, 1983·British Journal of Clinical Pharmacology·B G MitchellL F Prescott
Aug 1, 1982·British Journal of Clinical Pharmacology·E J BeggD N Wade
Apr 1, 1984·British Journal of Clinical Pharmacology·K A MuhiddinP Turner
Apr 1, 1986·Drug Intelligence & Clinical Pharmacy·B J Schrader, J L Bauman
Sep 1, 1982·British Journal of Clinical Pharmacology·D El AllafA Dresse

Citations

Aug 1, 1978·British Journal of Clinical Pharmacology·N P CampbellR G Shanks
Jun 1, 1974·British Journal of Clinical Pharmacology·M A KiddieT R Shaw

Related Concepts

Urine
Renal Elimination
Administration Procedure
Novo-Mexiletine
Propylamines
Pharmacologic Substance
Body Excretions
Plasma
Excretory Function
Mexiletine

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Related Papers

British Journal of Clinical Pharmacology
M A KiddieT R Shaw
British Journal of Clinical Pharmacology
N P CampbellR G Shanks
European Journal of Clinical Pharmacology
P J PentikäinenH A Hiltunen
British Journal of Clinical Pharmacology
N P CampbellR G Shanks
British Journal of Clinical Pharmacology
P HerzogE Jähnchen
© 2020 Meta ULC. All rights reserved